Based on our expertise in the field of mass spectrometry and proteomics and using up-to-date mass spectrometry instrumentation, our research projects are devoted to the understanding of biological processes involved mainly in cancer and inflammation. These projects include methodological developments in proteomic strategies focused on the analysis of protein complexes, the characterization of posttranslational modifications, the analysis of low-abundance proteins, and the identification of biomarker candidates. They rely on the use of a combination of optimized biochemistry steps (fractionation, enrichment), sophisticated global and targeted quantitative mass spectrometry-based proteomic analyses, and dedicated bioinformatics tools. The group is working using quality standards (ISO 9001 quality assurance certification since 2006) and has the national IBISA label for Proteomics Infrastructures.
Since 2011, the proteomics group is one of the three nodes of the French Proteomics Infrastructure, ProFI (“Investissements d’avenir” from the French Ministry of Research). This distributed infrastructure aims first at gathering complementary expertise in proteomics to develop new bioinformatic tools and to set-up efficient targeted and global quantitative proteomics workflows and second at collaborating with the scientific community to share knowledge and to handle challenging programs in proteomics.