New group leaders at the IPBS Institute, Toulouse, France
Founded in 1996, the Institute of Pharmacology and Structural Biology (IPBS) is a leading research institute of the French National Centre for Scientific Research (CNRS) and the University of Toulouse. Located on the main Campus of the Université Toulouse III-Paul Sabatier in Toulouse, southwest France, the IPBS offers multidisciplinary education in the fields of Science, Health, Engineering and Technology, developing one of the most important scientific research clusters in France.
Our Institute is a world leader in the discovery, characterization and validation of novel important pathways and pharmacological targets in the fields of cancer and infectious diseases, through the use of molecular and cellular biology approaches, together with in vivo experiments. It conducts state-of-the-art research in structural biology, proteomics, biophysics, cancerology, immunology and microbiology.
The IPBS brings together more than 250 scientists and supporting staffs, including more than 60 national and international postdoctoral fellows and PhD students. The IPBS offers outstanding scientific and stimulating research environment and several cutting-edge core facilities with highly qualified staff. These include mass spectrometry and proteomics, macromolecular crystallography, liquid- and solid-state NMR, biophysical characterization of proteins and complexes, virtual screening, whole body, tissue and cellular imaging, flow cytometry and cell sorting in standard or BSL3 environments, single particle tracking and tethered particle motion analysis, and animal facilities.
In order to reinforce its research endeavors in an inspiring, collaborative and cutting-edge environment, the IPBS is seeking new talented junior group leaders addressing fundamental questions within the spectrum of its research fields. Young scientists of any nationality, at junior or midcareer level, and with an excellent track record of publications in internationally recognized journals, are encouraged to apply. International experience as well as capacity to interact with other research groups within the institute are highly recommended.
Successful candidate(s) will be provided laboratory and office space for 5-8 people, a technical personnel and free access to the institute’s core facilities for a period of 2 years, together with a starting package for basic equipment and consumables. In addition, strong support will be provided from the IPBS to obtain tenured positions at CNRS, INSERM or the University of Toulouse. Outstanding candidates are expected to establish independent and vigorous national and international extramurally-funded research programs (ANR, ERC, etc.) that fit at least with one of the priority topics listed below. Researchers already holding a permanent position are also welcome to apply.
IPBS priority topics
See below full details for each topic
• Tumor microenvironment – Cancer immunology - Interactions of immune cells with stromal cells, the extracellular matrix and/or other immune cells; immune response to cancer.
• DNA repair/chromatin remodeling in cancer - DNA damage response (DDR) in connection with cancer through epigenetics, transcriptional regulation, DNA repair pathologies, chromosomal translocations, DDR-based drug discovery, or tumor resistance to clastogenic agents.
• Pulmonary infections - Biology of bacterial respiratory pathogens, including Mycobacterium tuberculosis and others, with a strong focus on mechanisms underlying pathogen’s persistence, drug resistance or tolerance within the host.
• Drug discovery & structural biology - Development of biological and chemical drugs of the future, with the aim of strengthening the pharmacological aspects of the IPBS research framework; characterization of drug-target interactions and mechanism of action; “hit to lead” strategies and new approaches for drug target deconvolution or vectorization will be favored. A particular attention will be given to candidates willing to create a group in biological NMR.
Procedure & calendar
Application (about 5 pages in English) should include a cover letter describing previous research experience, an outline of the future research project, motivation for joining the institute and names and e-mail address of 3 referees, together with an updated CV (including a complete list of publications). Application should be sent to firstname.lastname@example.org in a single PDF file named LASTNAME_FIRSTNAME_IPBS2017.pdf. Other formats will not be considered.