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A joint institute of CNRS and Paul Sabatier
University (University of Toulouse)
The main objective of the Institute is to characterize fundamental mechanisms that control the function of biological systems, by analyzing structure-function relationship of macromolecules, in order to develop pharmacological applications.
A primary objective is the identification and characterization of novel pharmacological targets in the fields of Cancer and Infectious Diseases (Tuberculosis).
The Institute is strongly committed to:
- Teaching: many IPBS scientists participate in undergraduate, master and doctoral programs of the Université de Toulouse ( in the "Biologie-Santé-Biotechnologie" graduate school of Paul Sabatier University )
- Technology transfers and industrial
partnerships
Departments and Scientific objectives
Major findings |
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Aude Ndong Saulière-Nzeh et al, Agonist-selective Dynamic Compartmentalization of Human Mu Opioid Receptor as Revealed by Resolutive FRAP Analysis, J. Biol. Chem. 2010 285: 14514-14520  more
Mouton-Barbosa et al (2010), In-depth Exploration of Cerebrospinal Fluid by Combining Peptide Ligand Library Treatment and Label-free Protein Quantification, Mol Cell Proteomics 2010 9: 1006-1021 more
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DNA POLYMERASES,
Discovery, Characterization and Functions in Cellular DNA Transactions
by Ulrich Hübscher (University of Zurich, Switzerland), Silvio Spadari (Institute of Molecular Genetics IGM-CNR, Italy), Giuseppe Villani (CNRS-Université Paul Sabatier, Toulouse, France), & Giovanni Maga (Institute of Molecular Genetics IGM-CNR, Italy)
http://www.worldscibooks.com/lifesci/7667.html |
Oriane Bombarde et al (2010), TRF2/RAP1 and DNA–PK mediate a double protection against joining at telomeric ends, EMBO journal, doi:10.1038/emboj.2010.49 more
Cougoule et al. (2010),Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis, Blood, 115(7), 1444-1452. more
Giglia-Mari G, et al. (2009) Differentiation Driven Changes in the Dynamic Organization of Basal Transcription Initiation. PLoS Biol 7(10): e1000220. doi:10.1371/ journal.pbio.1000220 more
Antoine Tanne et al. (2009) A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis,J. Exp. Med. 2009 206: 2205-2220 more
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Focus