Publications

2007

Puissegur M.-P., Lay G., Gilleron M., Botella L., Nigou J., Marrakchi H., Mari B., Duteyrat J.L., Guerardel Y., Kremer L., Barbry P., Puzo G. and Altare F. (2007). Mycobacterial LM induces Granuloma Macrophages fusion via a TLR2-dependent, ADAM9- and b1 Integrin- mediated pathway. J. Immunol., 178(5), 3161-9. 

Ragas A., Roussel L., Puzo G. and Riviere M. (2007). The Mycobacterium tuberculosis cell-surface glycoprotein apa as a potential adhesin to colonize target cells via the innate immune system pulmonary C-type lectin surfactant protein A. J. Biol. Chem., 282(8), 5133-5142. 

Gilleron M., Jackson M., Nigou J. and Puzo G. (2007). Structure, activities and biosynthesis of the phosphatidyl-myo-inositol-based lipoglycans. In X (Daffé, M., & Reyrat, J. M., eds), ASM Press, in press. 

Stadthagen G., Sambou T., Guerin M., Barilone N., Boudou F., Korduláková J., Charles P., Alzari P.M., Lemassu A., Daffé M., Puzo G., Gicquel B., Rivière M. and Jackson M. (2007). Genetic bases for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis. J. Biol. Chem., 282(37), 27270-6. 

Brown A.K., Meng G., Ghadbane H., Scott D.J., Dover L.G., Nigou J., Besra G.S. and Futterer K. (2007). Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+. BMC Struct. Biol., 7(1), 55. 

Doz E., Rose S., Nigou J., Gilleron M., Puzo G., Erard F., Ryffel B. and Quesniaux V.F. (2007). Acylation Determines the Toll-like receptor (TLR)-dependent Positive Versus TLR2-, Mannose Receptor-, and SIGNR1-independent Negative Regulation of Pro-inflammatory Cytokines by Mycobacterial Lipomannan. J. Biol. Chem., 282(36), 26014-26025. 

Dulphy, N., Herrmann, J.L., Nigou, J., Réa, D., Boissel, N., Puzo, G., Charron, D., Lagrange, P.H. and Toubert, A. (2007). Intermediate Maturation of M. tuberculosis-LAM activated Human Dendritic Cells. Cell Microbiol, 9(6), 1412-25. 

Mishra A.K., Alderwick L.J., Rittmann D., Tatituri R.V., Nigou J., Gilleron M., Eggeling L. and Besra G.S. (2007). Identification of an alpha(1-->6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis. Mol. Microbiol., 65(6), 1503-17. 

Rosas-Magallanes V., Stadthagen-Gomez G., Rauzier J., Barreiro L. B., Tailleux L., Boudou F., Griffin R., Nigou J., Jackson M., Gicquel B. and Neyrolles O. (2007). Signature-tagged Transposon Mutagenesis Identifies Novel Mycobacterium tuberculosis Genes Involved in the Parasitism of Human Macrophages. Infect Immun., 75(1), 504-507. 

Tatituri R. V., Illarionov P. A., Dover L. G., Nigou J., Gilleron M., Hitchen P. G., Krumbach K., Morris H. R., Spencer N., Dell A., Eggeling L. and Besra G. S. (2007). Inactivation of Corynebacterium glutamicum NCgl0452 and the role of MgtA in the biosynthesis of a novel mannosylated glycolipid involved in lipomannan biosynthesis. J. Biol. Chem., 282(7), 4561-4572. 

Tatituri R.V.V., Alderwick L.J., Mishra A.K., Nigou J., Gilleron M., Krumbach K. Hitchen P., Giordano A., Morris H.R., Dell A., Eggeling L. and Besra G.S. (2007). Identification and structural characterisation of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant. Microbiology, 153(Pt 8), 2621-9.

2006

Garcia-Alles L.F., Versluis K., Maveyraud L., Vallina A.T., Sansano S., Bello N.F., Gober H.J., Guillet V., De la Salle H., Puzo G., Mori L., Heck A., De Libero G. and Mourey L. (2006). Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b. EMBO J., 25, 3684-3692.

 Chaumontet M., Pons V., Marotte K. and Prandi J. (2006). Hydrolytically-stable Arabinofuranoside Analogs for the Synthesis of Arabinosyltransferase Inhibitors. Tetrahedron Lett., 47, 1113-1116.

 Gilleron M., Nigou J., Nicolle D., Quesniaux V. and Puzo G. (2006). The acylation state of mycobacterial lipomannans modulates innate immunity response through Toll-like receptor 2. Chem. Biol., 13, 39-47.

 Gilleron M., Lindner B. and Puzo G. (2006). A MS/MS approach for characterization of the fatty acid distribution on mycobacterial phosphatidyl-myo-inositol-mannosides. Anal. Chem., 78(24), 8543-8548.

 Herrmann J.L., Tailleux L., Nigou J., Gicquel B., Puzo G., Lagrange P. H. and Neyrolles O. (2006). Rôle des cellules dendritiques humaines dans la tuberculose : protecteur ou non protecteur ? Rev. Mal. Respir., suppl 3, 21-28.

2005

De La Salle H., Mariotti S., Angenieux C., Gilleron M., Garcia-Alles L.-F., Maître B., Malm D., Berg T., Mourey L., Salamero J., Cazenave J.P., Hanau D., Mori L., Puzo G., De Libero G. (2005). CD1e participates in processing of microbial glycolipid antigens. Science, 310, 5752, 1321-4.

 Gibson K. J. C., Gilleron M., Constant P., Sichi B., Puzo G., Besra G. S. and Nigou J. (2005). A lipomannan with strong TLR-2 dependant pro-inflammatory activity in Saccharothrix aerocolonigenes. J. Biol. Chem., 280(31), 28347-28356.

 Pitarque S., Herrmann J. L., Duteyrat J. L., Jackson M., Stewart G. R., Lecointe F., Payre B., Schwartz O., Young D. B., Marchal G., Lagrange P. H., Puzo G., Gicquel B., Nigou J. and Neyrolles O. (2005) Deciphering the molecular bases of Mycobacterium tuberculosis binding to DC-SIGN reveals an underestimated complexity. Biochem. J., 392(3), 615-24.

 Gilleron M., Garton, N. J., Nigou J., Brando T., Puzo G. and Sutcliffe I. C. (2005). Characterisation of a truncated lipoarabinomannan from the actinomycete Turicella otitidis. J. Bacteriol., 187(3), 854-61.

 Villeneuve C., Gilleron M., Maridonneau-Parini I., Daffé M., Astarié-Dequeker C. and Etienne G. (2005). Mycobacteria use their surface-exposed glycolipids to infect human macrophages through a receptor-dependent process. J Lipid Res., 46, 475-83.

2004

Gibson K.J.C., Gilleron M., Constant P., Brando T., Puzo G., Besra G. S. and Nigou J. (2004). Tsukamurella paurometabola lipoglycan : a new lipoarabinomannan variant with pro-inflammatory activity. J. Biol. Chem., 279, 22973-22982.

 Gilleron M., Stenger S., Mazorra Z., Wittke F., Mariotti S., Böhmer G., Prandi J., Mori L., Puzo G., and De Libero G. (2004). Diacylated sulfoglycolipids are novel mycobacterial antigens stimulating CD1-restricted T cells during infection with Mycobacterium tuberculosis. J. Exp. Med., 199 (5), 649-659.

 Joucla G., Brando T., Remaud-Simeon M., Monsan P. and Puzo P. (2004). Capillary electrophoresis analysis of glucooligosaccharide isomers. Electrophoresis, 25 (6), 861-869.

 Rivière M., Moisand A., Lopez A. and Puzo G. (2004). Biological activities of the mycobacterial lipoarabinomannan are dependent of their supra-molecular organization. J. Mol. Biol., 344 (4), 907-918.

 Quesniaux V. J., Nicolle D. M., Torres D., Kremer L., Guerardel Y., Nigou J., Puzo G., Erard F. and Ryffel B. (2004). TLR2-dependent positive and TLR2-independent negative regulation of proinflammatory cytokines by mycobacterial lipomannans. J. Immunol., 172(7), 4425-34.

 Nigou J., Gilleron M., Brando T. and Puzo G. (2004). Structural analysis of mycobacterial lipoglycans. Appl. Biochem. Biotechnol., 118 (1-3), 253-268.

2003

Gilleron M., Quesniaux V.F.J. and Puzo G. (2003). Acylation state of the Phosphatidyl Inositol Hexamannosides from Mycobacterium bovis BCG and its implication in TLR response". J. Biol. Chem., 278, 29880-29889.

Marotte K., Ayad T., Génisson Y., Besra G.S., Baltas M. and Prandi J. (2003). Synthesis and biological evaluation of iminosugar-oligoarabinofuranoside hybrids, a new class of mycobacterial arabinofuranosyltransferase inhibitors. Eur. J. Org. Chem., 2557-2565.

Marotte K., Sanchez S., Bamhaoud T. and Prandi J. (2003). Synthesis of oligoarabinofuranosides from the mycobacterial cell-wall. Eur. J. Org. Chem., 3587-3598.

Gibson K.J.C., Eggeling L., Maughan W.N., Krumbach K., Gurcha S.S., Nigou J., Puzo G., Sahm H. and Besra G.S. (2003). Disruption of Cg-Ppm1, a polyprenol monophosphomannose synthase and the generation of lipoglycan-less mutants in Corynebacterium glutamicum, a parallel metabolomic approach. J. Biol. Chem., 278(42), 40842-50.

Gibson K.L., Gilleron M., Constant P., Puzo G., Nigou J. and Besra G.S. (2003). Identification of a novel mannose-capped lipoarabinomannan in Amycolatopsis sulphurea. Biochem. J., 372(3), 821-829.

Gibson K.J.C., Gilleron M., Constant P., Puzo G., Nigou J. & Besra G.S. (2003). Structural and functional features of Rhodococcus ruber lipoarabinomannan. Microbiology, 149(6), 1437-1445.

Kordulakova J., Gilleron M., Puzo G., Brennan P.J., Gicquel B., Mikusova K. and Jackson M. (2003). Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of Mycobacterium species. J. Biol. Chem., 278(38), 36285-36295.

Maeda N., Nigou J., Herrmann J.L., Jackson M., Amara A., Lagrange P.H., Puzo G., Gicquel B. and Neyrolles O. (2003). The cell surface receptor DC-SIGN discriminates between Mycobacterium species through selective recognition of the mannose caps on lipoarabinomannan. J. Biol. Chem., 278(8), 5513-5516.

Nigou J., Gilleron M. and Puzo G. (2003). Lipoarabinomannans : from structure to biosynthesis. Biochimie, 85(1-2), 153-166.

Tailleux L., Maeda N., Nigou J., Gicquel B. and Neyrolles O. (2003). How is the phagocyte lectin keyboard played ? Master class lesson by Mycobacterium tuberculosis. Trends Microbiol., 11(6), 259-263.

2002

Brando T, Pardin C, Prandi J. and Puzo G. (2002). Analysis of aminofluorescein-fatty acid derivatives by capillary electrophoresis with laser-induced fluorescence detection at the attomole level : application to mycobacterial fatty acids. J Chromatogr A., 973(1-2), 203-210.

Garton N.J., Gilleron M., Brando T., Puzo G., Dan H.H., Giguere S., Prescott J.F. and Sutcliffe I.C. (2002). A novel lipoarabinomannan from the equine pathogen rhodococcus equi: structure and effect on macrophage cytokine production. J. Biol. Chem., 277, 31722-31733.

Ludwiczak P., Gilleron M., Bordat Y., Martin C., Gicquel B. and Puzo G. (2002). Mycobacterium tuberculosis phoP mutant : lipoarabinomannan molecular structure, Microbiology, 148, 3029-3037.

Nigou G., Gilleron M., Rojas M., Garcia L.F., Thurnher M. and Puzo G. (2002). Mycobacterial lipoarabinomannans : modulators of dendritic cell functions and apoptotic response. Microbes Infect., 4, 945-953.

Nigou J., Dover L.G. and Besra G.S. (2002). Purification and Biochemical Characterization of Mycobacterium tuberculosis SuhB, an Inositol Monophosphatase Involved in Inositol Biosynthesis. Biochemistry, 41(13), 4392-4398.

Nigou J and Besra G.S. (2002). Characterization and regulation of inositol monophosphatase activity in Mycobacterium smegmatis. Biochem. J., 361, 385-390.

Nigou J and Besra G.S. (2002). Cytidine diphosphate-diacylglycerol synthesis in Mycobacterium smegmatis. Biochem. J., 367, 157-162.

Sanchez S., Bamhaoud T. and Prandi J. (2002). Elaboration of Monoarabinofuranosidic Building Blocks. Eur. J. Org. Chem., 3864-3873.

Sidobre S., Puzo G. and Rivière M. (2002). Lipid restricted recognition of mycobacterial lipoglycans by human pulmonary surfactant protein A. A surface plasmon resonance study. Biochemical J., 365, 89-97.

Cooper H.N., Gurcha S.S., Nigou J., Brennan P.J., Belisle J.T., Besra G.S. and Young D. (2002). Characterization of mycobacterial protein glycosyltransferase activity using synthetic peptide acceptors in a cell-free assay. Glycobiology, 12, 427-434.

Kordulakova J., Gilleron M., Mikusova K., Puzo G., Brennan P.J., Gicquel B. and Jackson M. (2002). Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis: PimA is essential for growth of Mycobacteria. J. Biol. Chem., 277, 31335-31344.

Mempel M., Ronet C., Suarez F., Gilleron M., Puzo G., Kaer L.V., Lehuen A., Kourilsky P., and Gachelin G. (2002). Natural Killer T cells restricted by the monomorphic MHC class 1b CD1d1 Molecules behave like inflammatory cells. J. Immunol., 168, 365-371.

Nigou J., Gilleron M., Rojas M., Garcia L.F., Thurnher M. and Puzo G. (2002). Mycobacterial lipoarabinomannans: modulators of dendritic cell function and apoptotic response. Microbes Infect., 4, 945-953.

2001

Ludwiczak P., Brando T., Monsarrat B., and Puzo G. (2001). Structural characterization of Mycobacterium tuberculosis lipoarabinomannans by the combination of Capillary Electrophoresis and Matrix-assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry. Anal.Chem., 73, 2323-2330.

Moutel S. and Prandi J. (2001). Synthesis of Novel Analogues of the Calicheamicin g 1I and Esperamicin A1B Oligosaccharides. J. Chem. Soc., Perkin Trans 1, 305-315.

Nigou J., G., Zelle-Rieser C., Gilleron M., Thurner M. and Puzo G. (2001). Mannosylated lipoarabinomannans inhibit IL-12 production by human dendritic cells : evidence for a negative signal delivered through the mannose receptor. J. Immunol., 166, 7477-7485.

Prandi J. (2001). A general route to 4-C-branched sugars. Synthesis of methyl a-caryophylloside. Carbohydr. Res., 332, 241-247.

Gilleron M., Rivière M. and Puzo G. (2001). Roles of glycans in the bacterial infections: interaction host-mycobacteria in Glycans in Cell Interaction and Recognition: therapeutic aspects, edited by M. Aubery, 113-140.

2000

Prandi J. and Couturier G. (2000). Synthetis of methyl alpha-caryophylloside. Tetrahedron Lett., 41, 49-52.

Astarié-Dequeker C., Nigou J., Puzo G. and Maridonneau-Parini I. (2000). Mannosylated lipoarabinomannans activate the proteine tyrosine kinase Hck in human neutrophils. Infect. Immun., 68, 4827-4830.

Désiré J. and Prandi J. (2000). The Cobalt-Catalyzed Oxygenative Radical Route from Hexopyranosides to Carbapentofuranoses. Eur. J. Org. Chem., 3075-3084.

Gilleron M., Bala L., Brando T., Vercellone A. and Puzo G. (2000). "Mycobacterium tuberculosis H37Rv parietal and cellular lipoarabinomannans : characterization of the acyl-and glyco-forms". J. Biol. Chem., 275, 677-684.

Nigou J., Vercellone A. and Puzo G. (2000). New structural insights into the molecular deciphering of mycobacterial lipoglycan binding to C-type lectins: lipoarabinomannan glycoform characterization and quantification by capillary electrophoresis at the subnanomole level. J. Mol. Biol, 299(5), 1373-1382.

Rojas M., Garcia L.F., Nigou J., Puzo G. and Olivier M. (2000). Mannosylated lipoarabinomannans antagonizes Mycobacterium tuberculosis induced macrophage apoptosis by altering Ca++ dependant cell signaling. J. Infect. Disease, 182, 240-251.

Sidobre S., Nigou J., Puzo G. and Rivière M. (2000). "Lipoglycans Are Putative Ligands for the Human Pulmonary Surfactant Protein A Attachment to Mycobacteria. Critical role of the lipids for lectin-carbohydrate recognition" J Biol Chem., 275, 2415-2422.

Bamhaoud T., Sanchez S. and Prandi J. (2000). 1,2,5-ortho esters od D.Arabinose as versatile arabinofuranosidic building blocks. Concise synthesis of the tetrassccharidic cap of the lipoarabinomannan of Mycobacterium tuberculosis. Chem. Commun., 659-660.

Sanchez S., Bamhaoud T. and Prandi J. (2000). A comprehensive glycosylation system for the elaboration of oligoarabinofuranosides. Tetrahedron Lett., 41, 7447-7452.

Siebert H.C., André S., Asensio J.L., Canada F.J., Dong X., Espinosa J.F., Franck M., Gilleron M., Kaltner H., Kozar T., Bovin N.V., von der Lieth C.W., Vliegenthart J.F.G., Jimenez-Barbero J. and Gabius H.J. (2000). A new combined computational and NMR-spectroscopical strategy for the identification of additional constraints of the bound ligand in an aprotic solvent. Chem. Bio. Chem., 1, 181-195.

Nigou J., Monsarrat B., Gilleron M., Brando T., Albigot R. and Puzo G. (2000). Mycobacterial lipoglycans: Structure and roles in mycobacterial immunity. Dans Mass spectrometry in Biology & Medecine (Eds, A.L. Burlingame, S.A. Carr, M.A. Baldwin). Humana Press Inc., 463-480.

Gilleron M., Ronet C., Mempel M., Monsarrat B., Gachelin G. and Puzo G. (2001). Acylation state of phosphatidyl inositol mannosides from Mycobacterium bovis BCG and ability to induce granuloma and recruit NKT cells. J. Biol. Chem., 276 (37), 34896-34904.

1999

Monsarrat B., Brando T., Condouret P., Nigou J., and Puzo G. (1999). Characterization of mannooligosaccharide caps in mycobacterial Lipoarabinomannan by capillary zone electrophoresis-electrospray mass spectrometry. Glycobiology, 9, 335-342.

Gilleron M., Nigou J., Cahuzac B., and Puzo G. (1999). Structural study of the lipomannans from Mycobacterium bovis BCG : characterization of multiacylated forms of the phosphatidyl-myo-inositol anchor. J. Mol. Biol., 285, 2147-2160.

Nigou J., Gilleron M., and Puzo G. (1999). Lipoarabinomannans: Characterization of multiacylated forms of the phosphatidyl-myo-inositol anchor by Nuclear Magnetic Resonance spectroscopy. Biochemical J., 337, 453-460.

Astarie-Dequeker C., N’Diaye E., Le Cabec V., Rittig M. G., Prandi J., Maridonneau-Parini, I. (1999). The mannose receptor mediates uptake of pathogenic and nonpathogenic mycobacteria and bypasses bactericidal responses in human macrophages. Infec. Immun., 67, 469-477.

Nigou J., Gilleron M., Brando T., Vercellone A. and Puzo G. (1999). Structural definition of arabinomannans from Mycobacterium bovis BCG. Glycoconjugate J., 16, 6, 257-264.

Désiré J. and Prandi J. (1999). Synthesis of methyl beta-D-arabinofuranoside 5-[1D (and L)-myo-inositol 1-phosphate], the capping motif of the lipoarabinomannan of Mycobacterium smegmatis. Carbohydrate Res., 317, 110-118.

Romain F., Horn C., Pescher P., Namane A., Rivière M., Puzo G., Barzu O. and Marchal G. (1999). Deglycosylation of the 45/47-Kilodalton antigen complex of Mycobacterium tuberculosis decreases its capacity to elicit in vivo or in vitro cellular immune responses. Infect. Immun., 67 (11), 5567-5572.

Horn C., Namane A., Pescher P., Rivière M., Romain F., Puzo G., Barzu O., Marchal G. (1999). Decreased capacity of recombinant 45/47-kDa molecules (Apa) of mycobacterium tuberculosis to stimulate T lymphocyte responses related to changes in their mannosylation pattern. J. Biol. Chem., 274(45), 32023-30.

Gilleron M., Rivière M. and Puzo G. (1999). Vol. Glycans in Cell Interaction and Recognition : therapeutic aspects. Edited by M. Aubery, Roles of glycans in the bacterial infections : interaction host-mycobacteria.

Nigou J., Monsarrat B., Gilleron M., Brando T., Albigot R. and Puzo G. (1999). Mycobacterial lipoglycans : structures and roles in mycobacterial immunity. Mass Spectrometry in Biology and Medicine, Edits by A.L. Burlingame and M. A. Baldwin, 463-480.