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Dr. Frédéric J. Veyrier - Evolution of bacterial symbionts: from genomics to proteins function


Frédéric J. Veyrier

Institut National de la Recherche Scientifique, Université du Québec, Laval, Canada

Evolution of bacterial symbionts: from genomics to proteins function



In this talk I will discuss recent results from our group showing that the ancestor of N. meningitidis had undergone a rod-to-coccus cell-shape transition that came with modifications of the peptidoglycan and its immunological properties. We also described some of the genetics events responsible for these modifications and discovered new cell-shape determinant. A second example is the description of the gene acquisition and the subsequent evolution that produced one of the components of M. tuberculosis cell-envelop: the phenolic glycolipids.

We are now scaling up by reconstructing all the steps that allowed the genesis of the myco-envelop with the expectation to shed light on its unique symbiotic properties.

All together, our unique evolutionary approach is not only shedding light on novel function of often-unknown proteins but it is also allowing the description of key steps toward symbiosis and their consequences.



·      Veyrier FJ et al. 2015 Common cell shape evolution of two nasopharyngeal pathogens. PLOS Genet

·      Wang J, …, Veyrier FJ* & Behr MA*. 2015 Insights on the emergence of M. tuberculosis from the analysis of M. kansasii. Genome Biol Evol

·      Veyrier FJ et al. 2013 De-O-acetylation of peptidoglycan regulates glycan chain extension and affects in vivo survival of N. meningitidis. Mol Microbiol

·      Veyrier FJ et al. 2011 The rise and fall of the Mycobacterium tuberculosis genome Trends Microbiol

·      Veyrier FJ et al. 2011 A novel metal transporter mediating manganese export (MntX) regulates the Mn to Fe intracellular ratio and N. meningitidis virulence. PLOS Pathog



Note for visitors: Please come with a valid identity card

5 Sep

11:00 - 12:00

Seminar room - IPBS - Campus 205