Frédéric J. Veyrier
Institut National de la Recherche Scientifique, Université du Québec, Laval, Canada
Evolution of bacterial symbionts: from genomics to proteins function
In this talk I will discuss recent results from our group showing that the ancestor of N. meningitidis had undergone a rod-to-coccus cell-shape transition that came with modifications of the peptidoglycan and its immunological properties. We also described some of the genetics events responsible for these modifications and discovered new cell-shape determinant. A second example is the description of the gene acquisition and the subsequent evolution that produced one of the components of M. tuberculosis cell-envelop: the phenolic glycolipids.
We are now scaling up by reconstructing all the steps that allowed the genesis of the myco-envelop with the expectation to shed light on its unique symbiotic properties.
All together, our unique evolutionary approach is not only shedding light on novel function of often-unknown proteins but it is also allowing the description of key steps toward symbiosis and their consequences.
· Veyrier FJ et al. 2015 Common cell shape evolution of two nasopharyngeal pathogens. PLOS Genet
· Wang J, …, Veyrier FJ* & Behr MA*. 2015 Insights on the emergence of M. tuberculosis from the analysis of M. kansasii. Genome Biol Evol
· Veyrier FJ et al. 2013 De-O-acetylation of peptidoglycan regulates glycan chain extension and affects in vivo survival of N. meningitidis. Mol Microbiol
· Veyrier FJ et al. 2011 The rise and fall of the Mycobacterium tuberculosis genome Trends Microbiol
· Veyrier FJ et al. 2011 A novel metal transporter mediating manganese export (MntX) regulates the Mn to Fe intracellular ratio and N. meningitidis virulence. PLOS Pathog
Note for visitors: Please come with a valid identity card
11:00 - 12:00
Seminar room - IPBS - Campus 205