Guillaume Dumenil, Institut Pasteur, Paris
Bacterial infection of human vasculature can lead to unregulated systemic activation of coagulation and innate immunity and rapidly becomes life threatening. Neisseria meningitidis is a vascular pathogen that causes fatal septic shock and meningitis. Post-mortem histological analysis of tissues from individuals infected with N. meningitidis show large bacterial aggregates in close association with the vascular wall of small vessels. The ability of this bacterium to colonize blood vessel endothelium is likely to impact its capacity to both multiply in the blood stream and reach the brain. This process is referred to as vascular colonization. Recent work from our group exploring the early steps in N. meningitidis vascular colonization will be reported, from attachment to proliferation and dissemination, focusing on the bacterial–host interaction.
- Charles-Orszag A, Lemichez E, Tran Van Nhieu G, Dumenil G (2016) Microbial pathogenesis meets biomechanics. Curr Opin Cell Biol 38: 31-37.
- Imhaus AF, Dumenil G (2014) The number of Neisseria meningitidis type IV pili determines host cell interaction. EMBO J 33: 1767-1783.
- Melican K, Michea Veloso P, Martin T, Bruneval P, Dumenil G (2013) Adhesion of Neisseria meningitidis to dermal vessels leads to local vascular damage and purpura in a humanized mouse model. PLoS Pathog 9: e1003139.
- Chamot-Rooke J, Mikaty G, Malosse C, Soyer M, Dumont A, Gault J, Imhaus AF, Martin P, Trellet M, Clary G, Chafey P, Camoin L, Nilges M, Nassif X, Dumenil G (2011) Posttranslational modification of pili upon cell contact triggers N. meningitidis dissemination. Science 331: 778-782
11:00 - 12:00
Seminar room - IPBS - Campus 205