Skip to main content

Dr. Julie Déchanet-Merville - The response of gamma-delta T lymphocytes to Cytomegalovirus: conventional or unconventional?

J Déchanet.jpg

Julie Déchanet-Merville

CNRS UMR 5164 - Immuno ConcEpT, Bordeaux University

The response of gamma-delta T lymphocytes to Cytomegalovirus: conventional or unconventional?

Gamma-delta T cells are generally considered unconventional T cells because they are not restricted by MHC molecules, because they reside mainly in tissues and their response is often comparable to that of innate immune cells. The response of gamma-delta T cells to cytomegalovirus, however, has characteristics of adaptive immunity that questions this classification. This seminar will present the latest advances in this field, which covers the identification of antigens recognized by these lymphocytes, the analysis of their response in transplant patients and their clinical use.

Selected references

  • Marlin et al. 2017 Sensing of cell stress by human γδ TCR-dependent recognition of annexin A2. Proc Natl Acad Sci USA 114(12):3163-3168
  • Kaminski et al. 2016 Surveillance of γδ T cells predicts cytomegalovirus infection resolution in kidney transplants. J Am Soc Nephrol 27(2):637-45

 

Contact: Denis Hudrisier (denis.hudrisier@ipbs.fr)

Note for visitors: Please come with a valid identity card

 

12 Feb

11:00 - 12:00

Seminar room - IPBS - Campus 205