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Dr. Virginie Molle - From bacterial adaptation and survival during host-interactions towards identification of novel anti-infectious strategies

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Virginie Molle

Laboratoire dynamique des interactions membranaires normales et pathologiques (dImNP) - Montpellier

From bacterial adaptation and survival during host-interactions towards identification of novel anti-infectious strategies

In our group we are studying host-pathogen interactions and infectious processes in order to develop new anti-bacterial therapeutic strategies. We concentrate our efforts efforts on understanding the interactions of infected cells with their invading bacteria. Pathogens studied include mycobacterial species (Mycobacterium tuberculosis and Mycobacterium marinum), Salmonella typhimurium, Pseudomonas aeruginosa, Staphylococcus aureus, and Legionella pneumophila. Our main goal is to identify specific mechanisms involved in macrophage-pathogen interactions. Based on this knowledge, we develop novel anti-virulence strategies and specific zebrafish infectious models.

Selected references

  • L. Gannoun-Zaki, L. Pätzold, S. Huc-Brandt, G. Baronian, M. Ibrahem Elhawy, R. Gaupp, M. Martin, A-B Blanc-Potard, F. Letourneur, M. Bischoff and V. Molle (2018) PtpA, a secreted Staphylococcus aureus tyrosine phosphatase, contributes to virulence and interacts with host proteins during infection. Journal of Biological Chemistry 293(40):15569-15580
  • K. Bärlocher, C.A.J. Hutter, A.L. Swart, B. Steiner, A. Welin, M. Hohl, F. Letourneur, M.A. Seeger and H. Hilbi (2017) Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5. Nature Communications 8(1):1543
  • M. Rosas Olvera, E. Vivès, V. Molle, A-B. Blanc-Potard, and L. Gannoun-Zaki (2017) Endogenous and exogenous KdpF peptide increases susceptibility of Mycobacterium bovis BCG to nitrosative stress and reduces intramacrophage replication. Frontiers in Cellular and Infection Microbiology 7:115.

 

Contact: Céline Cougoule (celine.cougoule@ipbs.fr)

Note for visitors: Please come with a valid identity card

 

 

26 Mar

11:00 - 12:00

Seminar room - IPBS - Campus 205