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Dr. Xavier Montagutelli - Host genetics in the Collaborative Cross: from phenotypic diversity and new models to mechanisms and genes

 

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This seminar is co-orgnized by the IPBS and the Anexplo-Genotoul platform

Xavier Montagutelli

Institut Pasteur, Paris

Host genetics in the Collaborative Cross: from phenotypic diversity and new models to mechanisms and genes

Mouse models are developed to mimic conditions found in humans and to perform investigations under standardized and controlled condition. They also allow mechanistic studies through interventions which are not possible in humans for technical or ethical reasons. However, mouse models are often criticized for differences in clinical presentation with human conditions and for weak translatability of mouse results to humans. Since most mouse models have been produced on a single genetic background, they cannot pretend reproducing the phenotypic range observed in humans. Using experimental data produced by our group and others, we will illustrate how investigating the impact of large host genetic diversity using the Collaborative Cross mouse genetic reference population produces more relevant and diverse models for human diseases, and how genetic studies can lead to the discovery of new mechanisms and gene variants. We will propose a practical strategy applicable to any trait of interest.

Selected publications

  • Manet C, Simon-Loriere E, Jouvion G, Hardy D, Prot M, Conquet L, Flamand M, Panthier JJ, Sakuntabhai A, Montagutelli X. Genetic diversity of Collaborative Cross mice controls viral replication, clinical severity and brain pathology induced by Zika virus infection, independently of Oas1b. J Virol 2019 In press (PMID:31694939)
  • Panthier JJ, Montagutelli X. The Collaborative Cross, a groundbreaking tool to tackle complex traits. Med Sci (Paris) 2012 28(1):103-8
  • Zhang J, Malo D, Mott R, Panthier JJ, Montagutelli X, Jaubert J. Identification of new loci involved in the host susceptibility to Salmonella Typhimurium in collaborative cross mice. BMC Genomics 2018 19(1):303
  • Saul MC, Philip VM, Reinholdt LG, Center for Systems Neurogenetics of A, Chesler EJ. High-diversity mouse populations for complex traits. Trends Genet 2019 doi: 10.1016/j.tig.2019.04.003
  • Noll KE, Ferris MT, Heise MT. The Collaborative Cross: A systems genetics resource for studying host-pathogen interactions. Cell Host Microbe 2019 25(4):484-98

 

Contact: Olivier Neyrolles (neyrol@ipbs.fr), Magali Jacquier (magali.jacquier@ipbs.fr)

Note for visitors: Please come with a valid identity card

 

10 Dec

11:00 - 12:00

Seminar room - IPBS - Campus 205