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Dr. Zeev Ronai - Ubiquitin ligases in immune system attack of melanoma


IPBS Prestige Seminar

Zeev Ronai

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA, & The Technion Integrated Cancer Center, Israel Institute of Technology, Rappaport Medical school, Haifa, Israel

Ubiquitin ligases in immune system attack of melanoma

The Ronai lab has been studying the role of ubiquitin ligases Siah2 and RNF5 in tumor biology, with focus on changes that are primarily elicited in tumor cells, which determine their propensity to develop, progress, metastasize and resist therapy (PNAS 2008, Cancer Cell 2010, Cancer Cell 2013, Cell Reports 2015, Cancer Cell 2015). More recent studies have focused on the possibility that these ubiquitin ligases may be also engaged in the control of tumor immunity, altering immune cell recognition and attack of the tumors. With focus on melanoma, data will be presented for the role of Siah2 and RNF5 in regulation of immune cell components responsible for melanoma growth control and possible mechanisms that underlie such regulation.


Selected references

  • Qi J, Nakayama K, Cardiff RD, Borowsky AD, Kaul K, Williams R, Krajewski S, Mercola D, Carpenter PM, Bowtell D, Ronai ZA. Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell 2010 Jul 13
  • Kim H, Scimia MC, Wilkinson D, Trelles RD, Wood MR, Bowtell D, Dillin A, Mercola M, Ronai ZA. Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Mol Cell 2011 Nov 18
  • Lau E, Kluger H, Varsano T, Lee K, Scheffler I, Rimm DL, Ideker T, Ronai ZA. PKCℇ promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria Cell 2012 Feb 3
  • Qi J, Tripathi M, Mishra R, Sahgal N, Fazli L, Ettinger S, Placzek WJ, Claps G, Chung LW, Bowtell D, Gleave M, Bhowmick N, Ronai ZA. The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity. Cancer Cell 2013 Mar 18
  • Jeon YJ, Khelifa S, Ratnikov B, Scott DA, Feng Y, Parisi F, Ruller C, Lau E, Kim H, Brill LM, Jiang T, Rimm DL, Cardiff RD, Mills GB, Smith JW, Osterman AL, Kluger Y, Ronai ZA. Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-inducing Chemotherapies. Cancer Cell 2015 Mar 9
  • Feng Y, Pinkerton AB, Hulea L, Zhang T, Davies MA, Grotegut S, Cheli Y, Yin H, Lau E, Kim H, De SK, Barile E, Pellecchia M, Bosenberg M, Li JL, James B, Hassig CA, Brown KM, Topisirovic I, Ronai ZA. SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Research 2015 November 24


Contact : Laurence Nieto (

Note for visitors: Please come with a valid identity card


13 Mar

11:00 - 12:00

Fernand Gallais Conference room