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FRBT Prestige Conference - Protein targeting, secretion and quality control in bacteria

Prestige conference of the Fédération de Recherche en Biologie de Toulouse

Protein targeting, secretion and quality control in bacteria

 

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Dr. Wilbert Bitter

Vrije University and Amsterdam University Medical Center, Amsterdam, The Netherlands

Taking type VII secretion to the next level: maturation of substrates

Selected recent references

  • Phan et al. EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF. PLoS Pathog 2018 14(8):e1007247
  • Ates L et al. Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis. Nat Microbiol 2018 3(2):181-188
  • Boot et al. Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose. PLoS Genet 2017 13(12):e1007131
  • Ates et al. The ESX-5 system of pathogenic mycobacteria is involved in capsule integrity and virulence through its substrate PPE10. PLoS Pathog 2016 12(6):e1005696

 

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Dr. Axel Mogk

Zentrum für Molekular Biologie Heidelberg (ZMBH), University of Heidelberg, Germany

Toxic activation of an AAA+ protease

Selected recent references

  • Mogk et al. Cellular handling of protein agregates by disaggregation machines. Mol Cell 2018 69(2):214-226
  • Grousl et al. A prion-like domain in Hsp42 drives chaperone-facilitated aggregation of misfolded proteins. J Cell Biol 2018 217(4):1269-1285
  • Deville et al. Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase. Sci Adv.2017 3(8):e1701726
  • Carroni et al. Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control. Elife 2017 pii: e30120
  • Ungelenk et al. Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding. Nat Commun 2016 7:13673
  • Mogk & Bukau. Mitochondria tether protein trash to rejuvenate cellular environments. Cell 2014 159(3):471-2

 

Contact: Olivier Neyrolles (olivier.neyrolles@ipbs.fr) & Pierre Genevaux (pierre.genevaux@ibcg.biotoul.fr)

Note for visitors: Please come with a valid identity card

12 Apr

10:00 - 11:30

IBCG Conference room - CBI