Instituto Oswaldo Cruz, Fiocruz - Rio de Janeiro, Brazil
Mycobacterium bovis BCG Moreau and BCG vaccination in Brazil
Mycobacterium bovis BCG remains the only vaccine available against tuberculosis and has been in use for over ninety years. It is well known that the BCG strains used worldwide for vaccine production differ genetically, with potential impacts on vaccine efficacy. In Brazil, BCG strain Moreau has been in use since 1928 - the vaccine is given at birth, is provided freely by the Ministry of Health and also administered to contacts of leprosy patients. To fully characterized BCG Moreau, our group has sequenced its complete genome and characterized its secretome, comparing to that of BCG Pasteur. Our current aim is to understand the functional impact of selected mutations, mapped through comparative genomic analysis, contributing to the detailed molecular characterization of the Brazilian vaccine strain.
Contact: Christophe Guilhot (firstname.lastname@example.org)
Note for visitors: Please come with a valid identity card
11:00 - 12:00
Seminar room - IPBS - Campus 205