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Laure Gibot, Yoann Rombouts and Sébastien Britton, laureates of the ANR Young Researchers programme 2017

Three research associates from IPBS receive grants from the ANR Young Researchers programme 2017

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WHEEL - Electrostimulation of wound healing: towards a more effective therapy

Chronic wounds are a serious public health issue. Classical options for wound treatments are chemical, biological or mechanical debridement. However, some more innovative therapies are available. Among them, electrical stimulation is a promising technology, especially because it is based on a physical natural process and not on pharmacological drugs. The hypothesis of the WHEEL project is that electric parameters clinically used in electrochemotherapy and gene electrotransfer stimulate cells and promote cutaneous wound healing via induction of keratinocyte proliferation, migration and differentiation, extracellular matrix deposition by fibroblasts and promotion of angiogenesis. Thus, the objectives are to understand, visualize and quantify human cutaneous cell and tissue responses to this external electric field application.

 

MacGlycoTB - Deciphering the effector functions of ST8SIA4 and polysialylation in the immune response of macrophages against Mycobacterium tuberculosis

Successful parasitism of macrophages by Mycobacterium tuberculosis, the etiological agent of tuberculosis in humans, reflects the ability of the pathogen to subvert several cellular processes including fusion of phagosomes with lysosomes, antigen presentation, apoptosis, and the macrophage bactericidal responses. Glycan-mediated cellular interactions, especially via lectin receptors, are essential for the regulation and maintenance of the innate and adaptive immune systems. While it is known that M. tuberculosis infection modulates the glycosylation of host macrophages, the functional impact of host cell glycosylation on infection outcome and tuberculosis pathogenesis remains largely unknown. the MacGlycoTB project will investigate the role and mechanism of action of the polysialyltransferase ST8SIA4 and polysialic acid expressed by macrophages in the context of tuberculosis.

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DrugDR - Drugging DNA Repair complexes

The DrugDR project is aimed at developing a new approach for drug discovery that will combine phenotypic screening for drug identification on one hand, with chemoproteomics and functional genomics for drug target identification on the other hand. This original framework will be applied at identifying new druggable human DNA double-strand break (DSB) repair complexes, which are considered as valuable drug targets in multiple areas such as anticancer treatments, virus control and genome editing. Beyond the identification of new chemical modulators of human DNA repair, the set of techniques gathered through this project will be of great value to decipher the mechanism of action of multiple small molecules with interesting anticancer and antibacterial properties that have been discovered in Toulouse and that could transform into new therapies.