My interest in science always focused on the regulatory mechanisms allowing bacterial cells to adapt to their fluctuating environment. I have analyzed the regulators and the promoter regions of their target genes together with the molecular interactions involved in the transcriptional response to stresses such as elevated osmolarity or starvation upon entry into stationary phase, mostly in the bacterium Escherichia coli.
I joined the Neyrolles lab in 2011. I am studying the role of several so-called toxin/antitoxin systems (TA) in the major pathogen Mycobacterium tuberculosis (Mtb). TA systems are composed on the one hand of an endogenous toxic protein and, on the other hand, of an unstable antidote, most of the time a protein, able to neutralize the toxin in normal conditions, but rapidly degraded in specific stress conditions, resulting in growth arrest or bacterial cell death. Mtb genome encodes approximately 80 TA systems, a strikingly high number, as compared to the few systems present in most bacterial species.
In addition to TA systems, I am also interested in understanding how Mtb resist metal intoxication in phagocytes.
Professor at the University of Toulouse, I teach eukaryotic and bacterial genetics at the Licence and Master degrees.