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Mardi 29 avril 2004 à 11 heures
 Version
imprimable
Dr Anne EICHMANN
Directrice du Laboratoire de Médecine Expérimentale,
INSERM U36, Collège de France, Paris
Récepteurs de guidage axonal dans le développement vasculaire
Blood vessels and nerves are complex, branched structures that
share a high degree of anatomical similarity. Guidance of vessels
and nerves has to be exquisitely regulated to ensure proper wiring
of both systems. Several regulators of axon guidance have been
identified and some of these are also expressed in endothelial cells;
however, the extent to which their guidance functions are conserved
in the vascular system is still incompletely understood. We show
here that the repulsive netrin receptor UNC5B is expressed by
endothelial tip cells of the vascular system. Disruption of the
Unc5b gene in mice, or of Unc5b or netrin-1a in zebrafish, leads to
aberrant extension of endothelial tip cell filopodia, excessive
vessel branching and abnormal navigation. Netrin-1 causes
endothelial filopodial retraction, but only when UNC5B is present.
Thus, UNC5B functions as a repulsive netrin receptor in endothelial
cells controlling morphogenesis of the vascular system."
Réf : Lu, X., Le Noble, F., Yuan, L., Eichmann, A. (2004). "The
netrin receptor UNC5B mediates guidance events controlling
morphogenesis of the vascular system." Nature 432(7014): 179-86.
Contact :
Delphine Lacorre
Ce séminaire est donné dans le cadre de la soutenance de thèse de
Delphine Lacorre (équipe Jean-Philippe Girard)
SALLE FERNAND GALLAIS, Laboratoire de
Chimie de Coordination
205 route de Narbonne TOULOUSE CEDEX 4 |
