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Structure Gallery

 

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Crystal structure of the 4’-phosphopantetheinyl transferase PptT of Mycobacterium tunberculosis in complex with coenzyme A.

PDBid 4U89; unpublished

 

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Structure of the complex formed between the chaperone and the ChAD sequence of the M. tuberculosis TAC system. The molecular chaperone is made up of four identical subunits schematized as ribbons of different colours. Two ChAD peptides and the corresponding experimental electron density map (blue mesh) are also shown.
PDBid 5MTW ; Nat Commun, 2019

Density_DH_C12.pngCrystal structure of the DH domain of the polyketide synthase PpsC from Mycobacterium tunberculosis in complex with unsaturated trans-dodec-2-enoyl-CoA (C12:1-CoA).

PDBid 4OOC, 5L84, 5I0K, 5NJI; J. Mol. Biol., 2017

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Insight into structure-function relationships and inhibition of the fatty acyl-AMP ligase (FadD32) orthologs from mycobacteria. PDBid 5EY85EY9 ; J Biol Chem, 2016

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Structural insights into the carbohydrate-binding ability of an α-(1→2) branching sucrase from glycoside-hydrolase family 70 . PDBid 4TVD4TTU4TVC ; J Biol Chem, 2016

 

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Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach. PDBid 4TRN4TRO4TRM ; J Struct Biol, 2015

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Structural bases for N-glycan processing by mannoside-phosphorylase. PDBid 4UDG,4UDI4UDJ4UDK ; Acta cryst D, 2015

 

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Residues essential for panton-valentine leukocidin s component binding to its cell receptor suggest both plasticity and adaptability in its interaction surface. PDBid 4IYA,4IYC4IYT4IZL4J0O ; PLoS One, 2014

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First Structural Insights into alpha-L-Arabinofuranosidases from the Two GH62 Glycoside Hydrolase Subfamilies. PDBid 4N1I4N2R4N2Z4N4BJ Biol Chem, 2014

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ASNp double mutants as efficient glucosylation tools for chemo-enzymatic synthesis of bacterial oligosaccharides. PDBid 4FLO4FLQ4FLR4FLSJ.Am.Chem.Soc, 2012

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Acyltransferase domain from the mycobacterial polyketide synthase Pks13 in apo form or in complex with palmitoic acid or carboxypalmitoic acid. PDBid 3TZW3TZX3TZY,3TZZJ Biol Chem, 2012

 

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GBD-CD2: an α-(1→2) branching sucrase derived from DSR-E glucansucrase. PDBid3TTO3TTQJ Biol Chem, 2012

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Amylosucrase from Deinoccocus geothermalis in apo form or in complex with turanose. PDBid 3UCQ3UERJ Biol Chem, 2012

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Amylosucrase from Neisseria polysaccharea in complex with turanose. PDBid 3UEQJ Biol Chem, 2012

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Crystal structure of human CD1b in complex with synthetic antigenic diacylsulfoglycolipid and endogenous spacer. 
PDBid 3T8XProc Natl Acad Sci U S A, 2011

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Crystal structure of human CD1e. PDBid 3S6CProc Natl Acad Sci U S A, 2011

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Crystal structure of human GCP4. PDBid 3RIPNat Struct Mol Biol, 2011

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Lip2 lipase from Yarrowia lypolytica in its closed conformation. PDBid 3O0DBiophys J, 2010

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Mycobacterium tuberculosis methyltransferase Hma in complex with SADAE. PDBid3HA33HA53HA7J Biol Chem, 2009

 

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Staphylococcus aureus covalent S-F heterodimer of gamma-hemolysin. 
PDBid 2QK7Proteins, 2008

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SNA-II lectin from Sambucus nigra
PDBid 3CA03C9Z3CA13CA33CA43CA53CA63CAHProteins, 2009

 

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Native hCD1b in complex with phosphatidylcholine and a hydrophobic spacer. PDBid 2H26EMBO J, 2006

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Mycobacterium tuberculosis methyltransferase Hma in apo-form and in complex with SAM. PDBid 2FK72FK8J Biol Chem 2006

 

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Staphylococcus aureus Panton-Valentine leucocidin S component. PDBid 1T5RJ Biol Chem 2004