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Toulouse Proteomics Infrastructure

Odile Schiltz

Scientific Manager

Based on its expertise in the field of mass spectrometry and proteomics and using up-to-date mass spectrometry instrumentation and bioinformatics tools, the Proteomics Infrastructure of Toulouse proposes state-of-the-art analyses in proteomics to the academic and industrial scientific communities. The facility is able to handle programs in various areas from biology and health to agricultural applications.

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Proteomics is a rapidly evolving field regularly requiring the acquisition of new generations of mass spectrometry (MS) instrumentation. Up-to-date strategies are offered thanks to the integrated work and shared expertise of the research group with the collaborative projects from the infrastructure.

Depending on the objective of the projects, these are handled as individual analyses or as a collaborative study.

A contract can also be established with industrial partners. The proteomics infrastructure of Toulouse is certified ISO 9001 since 2006 and NFX 50-900 since 2014. In 2012 the French Proteomics Infrastructure (ProFI) has been created with two other proteomics groups in Grenoble and Strasbourg to increase research and development capabilities and competitiveness. The proteomics infrastructure of Toulouse offers several types of analyses that cover all aspects of proteomics from protein identification to large-scale differential quantitative analysis of complex proteomes. Post-translational modifications analysis either on a single protein or on a global scale can be performed as well as identification and quantification of protein partners. Targeted proteomics analyses have also been implemented for protein verification. The equipment is mainly based on MS instrumentation coupled to chromatographic systems (nanoLC-MS/MS) for data acquisition and on dedicated bioinformatics tools for data analysis.

 

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Britton S et al. (2014) DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal. Nucleic Acids Res, 42, 9047-62

Bray L et al. (2014) Identification and Functional Characterization of the Phosphorylation Sites of the Neuropeptide FF NPFF2 Receptor. J Biol Chem, 289(49): 33754-66

 

Soulet F et al. (2013) Mapping the extracellular and membrane proteome associated with the vasculature and the stroma in the embryo. Mol Cell Proteomics, 12(8):2293-312

 

Dray C et al. (2013) The Intestinal Glucose-Apelin Cycle Controls Carbohydrate Absorption in Mice. Gastroenterology, 144, 771-780
 

Valéra MC et al. (2012) Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the hematopoietic estrogen receptor α. Blood, 120(8):1703-12
 

 

Scientist

Anne Gonzalez de Peredo

CNRS Research associate in Biochemistry

Research Assistants

Renaud Albigot

CNRS Engineer in Bioinformatics

David Bouyssié

CNRS Engineer in Bioinformatics

Karima Chaoui

CNRS Engineer in Biochemistry and Mass Spectrometry

Carine Froment

CNRS Engineer in Biochemistry and Mass Spectrometry

Marlène Marcellin

CNRS Engineer in Biochemistry and Mass Spectrometry

Emmanuelle Mouton-Barbosa

University of Toulouse Engineer in Bioinformatics

Carole Pichereaux

CNRS Engineer in Biochemistry and Mass Spectrometry

Alexandre Stella

CNRS Engineer in Biochemistry and Mass Spectrometry

Research Assistants (Fixed-term Contract)

Mylène Camus

CNRS Engineer in Biochemistry and Mass Spectrometry

Audrey Gargaros

CNRS Engineer in Biochemistry and Mass Spectrometry

Julie Poisat

CNRS Engineer in Bioinformatics

Post-doctoral Fellow

Marie Locard-Paulet

Fellow of French Proteomics Infrastructure-Global Phosphoproteomics

The proteomics infrastructure offers several types of analysis that cover all aspects of proteomics and is also involved in several research projects in proteomics. To know more about us : http://proteomique.ipbs.fr/