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Tumor microenvironment – Cancer immunology

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Deciphering the influence of different cellular components of the tumor microenvironment, such as high endothelial venules (HEVs), which are portals of entry for lymphocytes into tumor tissues, mature adipocytes, dendritic cells and macrophages, on tumor progression is one of the major topics developed at IPBS. In addition, molecular aspects of cell migration and integration of biophysical parameters (such as matrix stiffness) are also studied. These projects benefit from cutting-edge technological facilities for whole body, tissue and cellular imaging (including intravital microscopy), flow cytometry and cell sorting, DONALD super-resolution microscope) and mass-spectrometry. In order to strengthen this topic, we are looking for a junior group leader with a genuine interest in studying immune components of the cancer microenvironment. Projects dealing with the followings will be favored: interaction of immune cells with stromal cells, the extracellular matrix and/or other immune cells; immune response to cancer.

Selected publications from our research teams

  • Bouissou et al (2017) Podosome force generation machinery: a local balance between protrusion at the core and traction at the ring. ACS Nano
  • Laurent et al (2016) Periprostatic adipose tissue acts as a driving force for the local invasion of prostate cancer in obesity: role of the CCR3/CCL7 axis. Nat Commun
  • Lafouresse et al. (2015) L-selectin controls trafficking of chronic lymphocytic leukemia cells in lymph node high endothelial venules in vivo. Blood
  • Lazar et al. (2016) Adipocyte exosomes promote melanoma aggressiveness through fatty acid oxidation: a novel mechanism linking obesity and cancer. Cancer Res
  • Proag et al. (2015) Working together: Spatial synchrony in the force and actin dynamics of podosome first neighbors. ACS Nano
  • Labernadie et al (2014) Protrusion force microscopy reveals oscillatory force generation and mechanosensing activity of human macrophage podosomes. Nat Commun
  • Lamsoul et al. (2013) ASB2α regulates migration of immature dendritic cells Blood
  • Bochet et al. (2013) Adipocyte-Derived Fibroblasts promote tumor progression and contribute to desmoplastic reaction in breast cancer. Cancer Res
  • Girard et al. (2012) HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes. Nat Rev Immunol
  • Dirat et al. (2011) Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res
  • Martinet et al. (2011) Human solid tumors contain high endothelial venules (HEV): association with T and B lymphocyte infiltration and favorable prognosis in breast cancer. Cancer Res
  • Moussion & Girard (2011) Dendritic cells control lymphocyte entry to lymph nodes via high endothelial venules Nature