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Corrine Cayrol

Current Position

Researcher at CNRS (French National Center for Scientific Research) (CR1) at the Institute of Pharmacology and Structural Biology (IPBS-UMR5089), 205 route de Narbonne, 31077 Toulouse cedex 04, FRANCE

Education - Training

  • 1989 : Biotechnology Engineer of the National Institute of Applied Sciences in Toulouse
  • 1989 : Master in Biotechnology of the University of Toulouse
  • 1992 : PhD in Immunology of the University of Toulouse (France), Laboratory : Research Center in Genetic Polymorphism (Dr Anne Camnbon-Thomsen)Subject : Class II HLA molecules : Characterization of new polymorphic epitope and study of intracellular traffic of HLA-DR and DQ molecules.
  • 1992-1995 : Postdoctoral fellow at HARVARD MEDICAL SCHOOL (Boston - USA) - Laboratory : Dana- Farber Cancer Institute (Pr Jack Strominger/Dr Erick Flemington) - Subject : Cellular targets of the Epstein-Barr virus transactivator Zta.
  • 1996-1998 : Postdoctoral fellow at the University of Toulouse ( France) - Laboratory : Institute of Pharmacology and Structural Biology (Pr Bernard Ducommun) - Subject : Mechanism of action of the cyclin dependent kinase inhibitor p21Cip1
  • 1998 : Permanent researcher position at CNRS
  • 1999-2003 : Laboratory : Institute of Pharmacology and Structural Biology (Dr Michel Wright)  Subject : Identification and characterization of new component of the mitotic checkpoint
  • Since 2004 : Laboratory : Institute of Pharmacology and Structural Biology, Cancer Biology Department, in the team ’Vascular Biology : Endothelial cells, inflammation and Cancer’ directed by Dr Jean-Philippe GIRARD - Subject : Functional and molecular characterization of two proteins (IL-33 and Thap1) from High Endothelial Venules


Main selected publications :

(full list of publications

Lefrançais E.§, Duval A.§, (§ : Co-first authors) Mirey E., Roga S., Espinosa E., Cayrol * C. and JP. Girard* (* : Co-senior authors) Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells. Proc Natl Acad Sci U S A. 2014 111(43):15502-7.

Lefrançais E, Roga S, Gautier V, Gonzalez-de-Peredo A, Monsarrat B, Girard JP and Cayrol C. IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G. Proc Natl Acad Sci U S A.2012 109(5):1673-8.

Gavarini, S., Cayrol C., Fuchs, T, Lyons, N., Ehrlich, ME., Girard* JP., and LJ. Ozelius*(* : co-senior authors) (2010) : A Direct Interaction between Causative Genes of DYT1 and DYT6 Primary Dystonia.Annals of Neurology 2010 68(4):549-53.

Mazars R*, Gonzalez-de-Peredo A*, Cayrol C*, Lavigne AC, Vogel JL, Ortega N, Lacroix C, Gautier V, Huet G, Ray A, Monsarrat B, Kristie TM, and J.P.Girard (* : co-first authors ) (2010) : The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias. J Biol Chem. 285(18):13364-71.

Cayrol., C. and J.P. Girard (2009) : The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1.Proc Natl Acad Sci U S A 106(22) : 9021-6.

Roussel L., Erard M., Cayrol., C. and J.P. Girard (2008) : Molecular mimicry between IL-33 and KSHV for attachment top chromatin through the H2A-H2B acidic pocket. EMBO reports vol 9(10) : 1006-1011.

Cayrol C., Lacroix C., Mathe C., Ecochard V., Ceribelli M., Loreau E., Lazar V., Dessen P., Mantovani R., Aguilar L. and J.P. Girard (2007) : The THAP-zinc finger protein THAP1 regulates endothelial cell proliferation through modulation of pRB/E2F cell-cycle target genes. Blood, 109 : 584-94

Roussigne M., Cayrol C., Clouaire T., Amalric F. and J.P. Girard (2003) : THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies. Oncogene, 22 : 2432-42.

Cayrol, C. and B. Ducommun (1998) : p21 mutants deficient for interaction with PCNA or cyclin dependent kinase show differential sensitivity to proteasome dependent degradation. Oncogene, 17 : 2437 -2444

Cayrol, C., Knibiehler, M. and B. Ducommun (1998) : p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells. Oncogene, 16:311-320

Cayrol, C., Cabrolier G. and B. Ducommun (1997) : Use of the two-hybrid system to identify protein-protein interactions temperature-sensitive mutants : application to the CDK2/p21Cip1 interaction. Nucleic Acid Research, 25 : 3743-3744

Cayrol, C. and E.K. Flemington. (1996) : G0/G1 growth arrest mediated by a region encompassing the basic leucine zipper (bZIP) domain of the Epstein-Barr virus transactivator Zta. Journal of Biological Chemistry., 271 : 31799-31802

Cayrol, C. and E.K. Flemington. (1996) : The Epstein-Barr virus bZIP transcription factor Zta causes G0/G1 cell-cycle arrest through induction of cyclin dependent kinase inhibitors. EMBO Journal 15 : 2748-2759

Cayrol, C., and E.K. Flemington. (1995) : Identification of cellular target genes of the Epstein-Barr virus transactivator Zta : Activation of Transforming growth factor bigh3 (TGF-βigh3) and TGF- β1. Journal of Virology, 69 : 4206-4212