A large part of the IPBS research activity is dedicated to studying various aspects of tuberculosis and other lung infections. This includes lipid biochemistry and biogenesis of the mycobacterial cell envelope, virulence mechanisms and host-pathogen interactions, and immunity to mycobacteria and other lung pathogens. We are looking for a junior group leader in the field of pulmonary bacterial infection, with a strong focus on the biology of pathogens. Topics related to the followings will be favored: mechanisms underlying pathogen’s persistence, drug resistance or tolerance within the host. Deciphering the mechanisms of bacteria adaptation to their microenvironment will be a central question, and will benefit from state-of-the art approaches including, but not restricted to, single cell analysis, omics, microscopy and structural biology. In particular, our BSL3 animal facilities are fully equipped tissue and cellular imaging (including multiphoton intravital microscopy) and flow cytometry and cell sorting.
Selected publications from our research teams
- Freire DM et al. (2019) An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death. Mol Cell.
- Augenstreich J et al. (2019) The conical shape of DIM lipids promotes Mycobacterium tuberculosis infection of macrophages. PNAS
- Souriant S et al. (2019) Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages. Cell Rep.
- Bénard A et al. (2018) B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis. Am J Respir Crit Care Med.
- Levillain F et al. (2017) Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation PLoS Pathog.
- Carel et al. (2017) Identification of specific posttranslational O-mycoloylations mediating protein targeting to the mycomembrane. PNAS
- Troegeler et al. (2017) C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells. PNAS
- Decout et al. (2017) Rational design of adjuvants targeting the C-type lectin Mincle. PNAS
- Boritsch et al. (2016) pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence. Nat Microbiol
- Gilleron M et al.(2016), Lysosomal Lipases PLRP2 and LPLA2 Process Mycobacterial Multi-acylated Lipids and Generate T Cell Stimulatory Antigens. Cell Chem Biol.
- Lastrucci et al. (2015) Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16+ monocyte population via the IL-10/STAT3 axis. Cell Res
- Gonzalo-Asensio et al. (2014) Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator. PNAS
- Gouzy et al. (2014) Nitrogen metabolism in Mycobacterium tuberculosis physiology and virulence. Nat Rev Microbiol
- Gavalda et al. (2014) The polyketide synthase Pks13 catalyzes a novel mechanism of lipid transfer in mycobacteria. Chem Biol
- Blattes et al. (2013) Mannodendrimers prevent acute lung inflammation by inhibiting neutrophil recruitment. PNAS
- Gouzy et al. (2013) Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate. Nat Chem Biol
- Liu et al. (2013) Bacterial protein-O-mannosylating enzyme is crucial for virulence of Mycobacterium tuberculosis. PNAS
- Botella et al. (2011) Mycobacterial P1-type ATPases mediate resistance to zinc poisoning in human macrophages. Cell Host Microbe