Structure Gallery

Crystal structure of the 4’-phosphopantetheinyl transferase PptT of Mycobacterium tunberculosis in complex with coenzyme A.

PDBid 4U89; unpublished

Structure of the complex formed between the chaperone and the ChAD sequence of the M. tuberculosis TAC system. The molecular chaperone is made up of four identical subunits schematized as ribbons of different colours. Two ChAD peptides and the corresponding experimental electron density map (blue mesh) are also shown.
PDBid 5MTW ; Nat Commun, 2019

Crystal structure of the DH domain of the polyketide synthase PpsC from Mycobacterium tunberculosis in complex with unsaturated trans-dodec-2-enoyl-CoA (C_12:1-CoA).

PDBid 4OOC, 5L84, 5I0K, 5NJI; J. Mol. Biol., 2017

Insight into structure-function relationships and inhibition of the fatty acyl-AMP ligase (FadD32) orthologs from mycobacteria. PDBid 5EY8, 5EY9 ; J Biol Chem, 2016

Structural insights into the carbohydrate-binding ability of an α-(1→2) branching sucrase from glycoside-hydrolase family 70 . PDBid 4TVD, 4TTU, 4TVC ; J Biol Chem, 2016

Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach. PDBid 4TRN, 4TRO, 4TRM ; J Struct Biol, 2015

Structural bases for N-glycan processing by mannoside-phosphorylase. PDBid 4UDG,4UDI, 4UDJ, 4UDK ; Acta cryst D, 2015

Residues essential for panton-valentine leukocidin s component binding to its cell receptor suggest both plasticity and adaptability in its interaction surface. PDBid 4IYA,4IYC, 4IYT, 4IZL, 4J0O ; PLoS One, 2014

First Structural Insights into alpha-L-Arabinofuranosidases from the Two GH62 Glycoside Hydrolase Subfamilies. PDBid 4N1I, 4N2R, 4N2Z, 4N4B; J Biol Chem, 2014

ASNp double mutants as efficient glucosylation tools for chemo-enzymatic synthesis of bacterial oligosaccharides. PDBid 4FLO, 4FLQ, 4FLR, 4FLS; J.Am.Chem.Soc, 2012

Acyltransferase domain from the mycobacterial polyketide synthase Pks13 in apo form or in complex with palmitoic acid or carboxypalmitoic acid. PDBid 3TZW, 3TZX, 3TZY,3TZZ; J Biol Chem, 2012

GBD-CD2: an α-(1→2) branching sucrase derived from DSR-E glucansucrase. PDBid3TTO, 3TTQ; J Biol Chem, 2012

Amylosucrase from Deinoccocus geothermalis in apo form or in complex with turanose. PDBid 3UCQ, 3UER; J Biol Chem, 2012

Amylosucrase from Neisseria polysaccharea in complex with turanose. PDBid 3UEQ; J Biol Chem, 2012

Crystal structure of human CD1b in complex with synthetic antigenic diacylsulfoglycolipid and endogenous spacer. 
PDBid 3T8X; Proc Natl Acad Sci U S A, 2011

Crystal structure of human CD1e. PDBid 3S6C; Proc Natl Acad Sci U S A, 2011

Crystal structure of human GCP4. PDBid 3RIP; Nat Struct Mol Biol, 2011

Lip2 lipase from Yarrowia lypolytica in its closed conformation. PDBid 3O0D; Biophys J, 2010

Mycobacterium tuberculosis methyltransferase Hma in complex with SADAE. PDBid3HA3, 3HA5, 3HA7; J Biol Chem, 2009

Staphylococcus aureus covalent S-F heterodimer of gamma-hemolysin. 
PDBid 2QK7; Proteins, 2008

SNA-II lectin from Sambucus nigra. 
PDBid 3CA0, 3C9Z, 3CA1, 3CA3, 3CA4, 3CA5, 3CA6, 3CAH; Proteins, 2009

Native hCD1b in complex with phosphatidylcholine and a hydrophobic spacer. PDBid 2H26; EMBO J, 2006

Mycobacterium tuberculosis methyltransferase Hma in apo-form and in complex with SAM. PDBid 2FK7, 2FK8; J Biol Chem 2006

Staphylococcus aureus Panton-Valentine leucocidin S component. PDBid 1T5R; J Biol Chem 2004