Better understanding towards better therapeutics in Cancer, Infection and Inflammation.
Cystic fibrosis is the most common rare genetic disease. In these patients, respiratory infections contribute to the loss of lung
Raising awareness, training and promoting the value of committed staff and structures are essential to the success of the CNRS
Of the four fundamental macromolecular components necessary for life, complex carbohydrates, or glycans, are probably the most structurally diverse. Glycans
O. Neyrolles, Director of Research at the CNRS and Director of the IPBS, and his team work on host-pathogen interactions
IPBS-Toulouse, Hybrid Seminar (seminar room)
Auditorium Marthe Condat
IPBS-Toulouse, Seminar room
Fernand Gallais Conference room
Pinilla et al. (2023) EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption. J Exp Med 220(10): e20230104
Mascarau et al. (2023) Productive HIV-1 infection of tissue macrophages by fusion with infected CD4+ T cells. J Cell Biol 222: e202205103
Viljoen*, Vercellone* et al. (2023) Nanoscale clustering of mycobacterial ligands and DC-SIGN host receptors are key determinants for pathogen recognition. Sci Adv 9(20): eadf9498
Seif-El-Dahan M*, Kefala-Stavridi A*, Frit P*, Hardwick SW* et al. (2023) PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv 9(22): eadg2834
Voisinne*, Locard-Paulet* et al. (2022) Kinetic proofreading through the multi-step activation of the ZAP70 kinase underlies early T cell ligand discrimination. Nat Immunol 23:1355-1364
Boudehen*, Faucher* et al. (2022) Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms. Nat Commun 13: 4731
Mosquera-Restrepo et al. (2022) A M. tuberculosis fingerprint in human breath allows tuberculosis detection. Nat Commun 13: 7751
Planès*, Pinilla*, Santoni*, Hessel*, Passemar* et al. (2022) Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells. Mol Cell 82: 2385-2400.e9
Asrir*, Tardiveau*, Coudert*, Laffont*, Blanchard* et al. (2022) Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy. Cancer Cell 40: 318-334.e9
Demange*, Joly*, Marcoux* et al. (2022) SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species. Elife 11: e73913
The IPBS is a joint research center of the CNRS and the University of Toulouse. Occupying 12,000 m2 in the heart of the main campus of the University of Toulouse III-Paul Sabatier, which offers high-level multidisciplinary training in the fields of science, health and engineering, the IPBS is part of one of the most important scientific research poles in health and biological sciences in France.
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