Better understanding towards better therapeutics in Cancer, Infection and Inflammation.
As part of Breast Cancer Awareness Month, IPBS is highlighting its commitment to breast cancer research through several projects and funding initiatives that are strengthening the scientific capabilities of its research teams.
The IPBS (Institute of Pharmacology and Structural Biology) is seeking motivated PhD candidates as part of the BEST Doctoral Programme
CNRS Innovation has awarded pre-maturation funding to the REHOME project, led by Yoann Rombouts, a CNRS researcher in Olivier Neyrolles’
An international team of researchers has discovered how a molecule normally used by the immune system to fight infection is
Živković*, Bosc-Rosati*, Sanchez Dafun* et al. (2026) PA200 modulates immunoproteasome structure and activity. Nat Commun DOI 10.1038/s41467-026-75325-w
Shin*, Hernandez* et al. (2026) Red bone marrow hosts metabolically active anucleate adipocytes that support hematopoiesis. Cell Rep DOI: 10.1016/j.celrep.2026.117602
Tamhaev et al. (2026) Rational design of diaryl ether-based dual inhibitors targeting successive essential enzymes HadAB and InhA in Mycobacterium tuberculosis. J Med Chem DOI: 10.1021/acs.jmedchem.6c01302
Gelon et al. (2026) Structural and functional consequences of IL33 and IL1RL1 coding variants on IL-33/ST2 signaling. Genes Immun DOI: 10.1038/s41435-026-00410-5
Dupuy et al. (2026) Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis. EMBO J DOI: 10.1038/s44318-026-00715-1
Lin et al. (2026) Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting. Nat Commun DOI: 10.1038/s41467-026-72734-9
Zahid*, Chauvat*, Ceppi*, Cappiello*, Perdichizzi* et al. (2026) Structural basis of Ku-mediated activation of WRN exonuclease activity. Nat Commun DOI: 10.1038/s41467-026-71888-w
Dufrançais et al. (2025) Moesin controls cell-cell fusion and osteoclast function. J Cell Biol 224(11):e202409169
Valderrama*, Horlacher*, Publicola* et al. (2026) Optimizing the antibiotic potency and metabolic stability of pyridomycin using a semi-synthetic approach. J Med Chem DOI: 10.1021/acs.jmedchem.5c02409
Gelon et al. (2026) The alarmin Interleukin-33 modulates platelet proteome, function and biogenesis. Blood Adv DOI: 10.1182/bloodadvances.2025018363
Frit*, Amin*, Zahid*, Barboule* et al. (2025) Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ. Nat Commun 16(1):4208
Blanchard*, Vina* et al. (2025) Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade. Cell Rep Med
Le Mouëllic et al. (2025) Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance. Proc Natl Acad Sci USA 122 (39) e2503966122
de Caro et al. (2025) New effective and less painful high frequency electrochemotherapy protocols: From optimization on 3D models to pilot study on veterinary patients. J Control Release 381:113592
Gorse*, Plessis*, Wearne*, Paradis*, Pinilla*, Chua* et al. (2025) Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation. EMBO Mol Med DOI: 10.1038/s44321-025-00197-4
Kralj et al. (2025) Dynamically assembling magnetic nanochains as new generation of swarm-type magneto-mechanical nanorobots affecting biofilm integrity. Adv Healthc Mater DOI: 10.1002/adhm.202403736
The IPBS is a joint research center of the CNRS and the University of Toulouse. Occupying 12,000 m2 in the heart of the main campus of the University of Toulouse III-Paul Sabatier, which offers high-level multidisciplinary training in the fields of science, health and engineering, the IPBS is part of one of the most important scientific research poles in health and biological sciences in France.
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