Better understanding towards better therapeutics in Cancer, Infection and Inflammation.
Since January 2024, the Institute of Pharmacology and Structural Biology (IPBS), represented by the Microenvironment, Cancer and Adipocytes team, has
IPBS is pleased to welcome three new research scientists and faculty members who will strengthen its teams and contribute to
Long considered a passive structural component, bone marrow adipose tissue is now emerging as a key component of the bone
Virginie Stévenin has been awarded an ATIP-Avenir grant, which will support for five years the research of her team, Cell
Fernand Gallais Conference room
Shin*, Hernandez* et al. (2026) Red bone marrow hosts metabolically active anucleate adipocytes that support hematopoiesis. Cell Rep DOI: 10.1016/j.celrep.2026.117602
Tamhaev et al. (2026) Rational design of diaryl ether-based dual inhibitors targeting successive essential enzymes HadAB and InhA in Mycobacterium tuberculosis. J Med Chem DOI: 10.1021/acs.jmedchem.6c01302
Dupuy et al. (2026) Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis. EMBO J DOI: 10.1038/s44318-026-00715-1
Lin et al. (2026) Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting. Nat Commun DOI: 10.1038/s41467-026-72734-9
Zahid*, Chauvat*, Ceppi*, Cappiello*, Perdichizzi* et al. (2026) Structural basis of Ku-mediated activation of WRN exonuclease activity. Nat Commun DOI: 10.1038/s41467-026-71888-w
Dufrançais et al. (2025) Moesin controls cell-cell fusion and osteoclast function. J Cell Biol 224(11):e202409169
Valderrama*, Horlacher*, Publicola* et al. (2026) Optimizing the antibiotic potency and metabolic stability of pyridomycin using a semi-synthetic approach. J Med Chem DOI: 10.1021/acs.jmedchem.5c02409
Gelon et al. (2026) The alarmin Interleukin-33 modulates platelet proteome, function and biogenesis. Blood Adv DOI: 10.1182/bloodadvances.2025018363
Frit*, Amin*, Zahid*, Barboule* et al. (2025) Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ. Nat Commun 16(1):4208
Blanchard*, Vina* et al. (2025) Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade. Cell Rep Med
Le Mouëllic et al. (2025) Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance. Proc Natl Acad Sci USA 122 (39) e2503966122
de Caro et al. (2025) New effective and less painful high frequency electrochemotherapy protocols: From optimization on 3D models to pilot study on veterinary patients. J Control Release 381:113592
Gorse*, Plessis*, Wearne*, Paradis*, Pinilla*, Chua* et al. (2025) Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation. EMBO Mol Med DOI: 10.1038/s44321-025-00197-4
Kralj et al. (2025) Dynamically assembling magnetic nanochains as new generation of swarm-type magneto-mechanical nanorobots affecting biofilm integrity. Adv Healthc Mater DOI: 10.1002/adhm.202403736
The IPBS is a joint research center of the CNRS and the University of Toulouse. Occupying 12,000 m2 in the heart of the main campus of the University of Toulouse III-Paul Sabatier, which offers high-level multidisciplinary training in the fields of science, health and engineering, the IPBS is part of one of the most important scientific research poles in health and biological sciences in France.
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