Alexia de Caro receives the Thesis Prize from the Toulouse Cancer Santé Foundation

Electrochemotherapy is an efficient physical method improving the delivery of certain anticancer agents. Yet, the method requires loco-regional or general anesthesia, as electrical pulses cause muscle contractions and pain.
With the aim to reduce the pain associated with muscular contractions; while maintaining the effectiveness of tumor treatments, Alexia de Caro, during her PhD thesis, developed new protocols using a high-frequency generator associated to a multipolar electrode, and tested it on multiple cellular models and veterinary patients (cats and horses).
The findings of her research, conducted with industrial partner Leroy Biotech and veterinarians from multiple veterinary facilities in Toulouse, highlight the efficacy of the treatment, allowing to treat mildly sedated patients, reducing anesthesia-related risks and improving patient welfare. These results pave the way for broader clinical applications of high-frequency electrochemotherapy in veterinary oncology and provide a strong foundation for future translational research in human medicine.