Anne-Sophie Beignon
U1184 IMVA-HB/IDMIT (CEA-INSERM-Université Paris Saclay)
Vaccine-induced memories
Epidemiological studies initially revealed that certain live attenuated vaccines, such as the tuberculosis vaccine, BCG, the oral polio vaccine, the measles vaccine, or the smallpox vaccine, provide protection beyond their targeted pathogens, decreasing overall mortality and morbidity. Several mechanisms have been proposed to explain these heterologous non-specific effects (NSE) of vaccines, including the induction of cross-reactive B and T cells, the bystander activation of specific T cells, and the establishment of an innate immune memory conferring a non-specific trained immunity.
We are investigating the mechanisms leading to trained immunity in non-human primates immunized with the smallpox and Mpox vaccine, MVA, and with BCG, in collaboration with Roland Brosch. We study blood myeloid cells and myelopoeisis. Deciphering the mechanisms at play should contribute to harness innate memory to improve responses to vaccines.
Selected references
- Feraoun Y, Palgen JL, Joly C, Tchitchek N, Marcos-Lopez E, Dereuddre-Bosquet N, Gallouet AS, Contreras V, Lévy Y, Martinon F, Le Grand R, Beignon AS. The Route of Vaccine Administration Determines Whether Blood Neutrophils Undergo Long-Term Phenotypic Modifications. Front Immunol. 2022 Jan 4;12:784813
- Palgen JL, Feraoun Y, Dzangué-Tchoupou G, Joly C, Martinon F, Le Grand R, Beignon AS. Optimize Prime/Boost Vaccine Strategies: Trained Immunity as a New Player in the Game. Front Immunol. 2021 Mar 8;12:612747
- Palgen JL, Tchitchek N, Rodriguez-Pozo A, Jouhault Q, Abdelhouahab H, Dereuddre-Bosquet N, Contreras V, Martinon F, Cosma A, Lévy Y, Le Grand R, Beignon AS. Innate and secondary humoral responses are improved by increasing the time between MVA vaccine immunizations. NPJ Vaccines. 2020 Mar 19;5(1):24
- Palgen JL, Tchitchek N, Elhmouzi-Younes J, Delandre S, Namet I, Rosenbaum P, Dereuddre-Bosquet N, Martinon F, Cosma A, Lévy Y, Le Grand R, Beignon AS. Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response. Sci Rep. 2018 Feb 15;8(1):3087