Mycobacterial Interactions with Host Cells
Group Leader
The main goal of our research group is to better understand host-pathogen interactions in tuberculosis on the molecular and cellular levels, from the discovery of novel virulence genes in M. tuberculosis to the identification of immune mechanisms involved in host defense against the pathogen, with the overall objective of proposing better strategies to control disease.
We study host-pathogen interactions in tuberculosis, with a special interest in deciphering immunity to TB and the links between M. tuberculosis evolution, physiology and virulence.
Our research aims at exploring the links between metabolism and virulence in the TB bacillus, Mycobacterium tuberculosis, and how this link was shaped throughout evolution. In particular, we use dual global gene expression profiling (RNA-seq) and transposon mutant library screening (Tn-seq) to identify genes and pathways playing a part in host-pathogen interactions in TB. We especially identified a novel mechanism of innate immune control of pathogens through zinc intoxication, and resistance strategies in pathogenic mycobacteria involving P-ATPases were discovered. We are currently deciphering the function of several P-ATPases in M. tuberculosis physiology and virulence. We also use dual RNA-seq analysis and Tn-seq analysis to understand M. tuberculosis adaptation to various host-imposed stresses, including hypoxia.
Our lab is also interested in understanding immunity to TB in absence and presence of co-infection with the AIDS virus HIV-1. In this context, we are deciphering the role of innate receptors, in particular C-type lectins, and host cell-expressed glycans in anti-mycobacterial immunity. As an example, we recently found that the C-type lectin DCIR modulates immunity to TB by sustaining type I interferon signaling in dendritic cells. The molecular mechanisms involved in DCIR signaling are being deciphered through biochemical and (phospho)proteomic experiments.
We are also exploring the role played by lymphocytes and innate lymphoid cells (ILCs) in immunity to TB. The contribution of ILCs to the immune response against M. tuberculosis is poorly known and our recent data indicate that TB infection induces some metabolism-driven phenotypic plasticity in the ILC compartment conferring an early protection against M. tuberculosis. Regarding other lymphocytes, we are currently developing imaging and functional approaches to understand which subpopulations of T lymphocytes have the best access, interaction and functional properties to reach M. tuberculosis infected cells.
Finally, in the context of TB/HIV co-infection, a predominant hypothesis to explain exacerbation of HIV-1 infection is that infection of macrophages by M. tuberculosis modulates the local inflammatory environments in favor of HIV-1 replication. We are currently exploiting different in vitro approaches to mimic this “bystander” effect emanating from sites of M. tuberculosis infection to dissect the molecular and cellular mechanisms rendering human monocytes and macrophages susceptible to HIV-1 infection. In parallel, within the context of co-infection in vivo, we establish crucial correlations of our in vitro findings in pulmonary lesions of non-human primates and human samples, including sera and pleural effusion fluid. Altogether, our ultimate goal is to deliver novel targets for diagnostic and therapeutic potential against co-morbidity established between AIDS and TB.
Team members
Research Scientists
Claude Gutierrez (University)
Denis Hudrisier (University)
Fabien Letisse (University)
Geanncarlo Lugo (CNRS)
Olivier Neyrolles (CNRS)
Yannick Poquet (University)
Yoann Rombouts (CNRS)
Research Engineers
Nelly Gilles
Florence Levillain (CNRS)
Bertille Voisin
Postdoctoral Fellows
Pierre Dupuy
Marion Faucher
PhD Students
Rim Abderrahim
Louis Benastre
Maxime Caouaille
Natacha Faivre
Wendy Le Mouellic
Sarah Monard
Stella Rousset
Our research projects
Boudehen*, Faucher* et al. (2022) Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms. Nat Commun
Corral et al. (2022) ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection. Cell Rep
Souriant et al. (2019) Tuberculosis exacerbates HIV-1 infection through IL-10/STAT3-dependent tunneling nanotube formation in macrophages. Cell Rep
Troegeler et al. (2017) C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells. Proc Natl Acad Sci USA
Freire*, Gutierrez* et al. (2019) An NAD+ phosphorylase toxin triggers Mycobacterium tuberculosis cell death. Mol Cell
Levillain*, Poquet* et al. (2017) Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation. PLOS Pathog
Confocal microscopy imaging of functional membrane micro domains (blue) in Mycobacterium tuberculosis © Y.-M. Boudehen
Prizes
October 2021 – Olivier Neyrolles is awarded the CNRS silver medal. Read more… (in French)
November 2020 – Olivier Neyrolles is awarded the Jacques Piraud Prize from the Fondation pour la Recherche Médicale.
October 2018 – The 2018 PEPS Prize for Pedagogical Innovation is awarded to the IMMUNOVA project (Active, interactive and flexible learning in immunology) led by Denis Hudrisier.
The IMMUNOVA project is composed of two axes: the first is the strong use of digital resources allowing the students to prepare themselves before and after the face-to-face sessions (also available online), which provides greater flexibility and learning autonomy for all students, especially those who cannot attend classes according to established schedules; for the second axis, the students are offered to conduct team projects in immunology according to different approaches (e.g., digital resource generation, interviews with researchers, 3D printing of proteins in FabLabs, conception of serious games).
Known more about the project – Watch the video! (in French)
December 2017 – Anthony Troegeler is awarded the Bretesche Prize in medicine from the Toulouse Academy of sciences.
Anthony did his PhD studies in our lab where he worked on the role of the innate immune receptor DCIR in immunity to tuberculosis. His work was published in January 2017 in Proc Natl Acad Sci USA. He will receive the Prize on December 3 at the Hôtel d’Assézat, Toulouse.
June 2017 – Yoann Rombouts is awarded the IGO Young Glycoscientist Award 2017.
December 2016 – Olivier Neyrolles receives the Sanofi-Institut Pasteur National Junior Award in the field of neglected tropical diseases for his research into tuberculosis, during a ceremony at the Institut Pasteur, Paris. Olivier and his team contributed to understanding several aspects of the complex interactions between the tuberculosis bacillus, Mycobacterium tuberculosis, and its host, including anti-mycobacterial immunity and mycobacterial evolution, physiology and virulence…
December 2014 – Alexandre Gouzy receives the Sanofi 2014 Prize from the Toulouse Academy of Sciences.
February 2014 – Olivier Neyrolles receives the “Coup d’élan pour la Recherche Française” Prize from the Bettencourt Schueller Foundation during a ceremony at the Institut de France, Paris, in which Madame F. Bettencourt Meyers presented the Prize. This Prize rewards teams specifically chosen for the promising nature of their research programs. The Prize recognises both the quality of the work of Olivier Neyrolles’ team and the quality of the research conducted in the Tuberculosis & Infection Biology Department at IPBS in the field of vaccine and antibiotics development.
April 2012 – Hélène Botella, winner of the AXA-Academy of Sciences prize based on her work in the involvement of zinc as a natural mechanism to fight against infections.
2009 – Olivier Neyrolles receives the CNRS Bronze medal.
Press Releases
How the tuberculosis bacillus takes advantage of the lipids of its host
Siglec-1: Bridging the synergy between Mycobacterium tuberculosis and HIV-1
How the tuberculosis bacillus learned to respire in the absence of oxygen
A new target to fight tuberculosis: a population of immune cells favourable to the resilience of the bacillus… Press release in french
Collaborations
We are indebtful to our many national and international collaborators, including:
- Joel Ernst University of California, San Francisco, CA, USA
- Sho Yamasaki Research Institute for Microbial Diseases, Osaka, Japan
- Elsa Anes University of Lisbon, Portugal
- David Sancho National Cardiovascular Research Centre, Madrid, Spain
- Patrice Catty Commissariat à l’Energie Atomique, Grenoble, France
- Brigitte Gicquel, Ludovic Tailleux, Roland Brosch, Pierre Charneau & Lluis Quintana-Murci Institut Pasteur, Paris
- Matthias Willmans EMBL-Centre for Cellular and Molecular Imaging, Hamburg, Germany
- Manfred Wuhrer Leiden University Medical Centre, Leiden, The Netherlands
- Marcelo Kuroda University of California, Davis, CA, USA
- Luciana Balboa & Maria Carmen Sasiain Academia Nacional de Medicina, Buenos Aires, Argentina
- Luiz Pedro de Carvalho The Francis Crick Institute, London, UK
Funding
Our team is supported by several grants and fellowships from:
- European Union (FP7, H2020, Horizon Europe)
- ERA-NET JPI-AMR
- European Respiratory Society
- MSDAVENIR
- NIH
- Agence Nationale de la Recherche
- Agence Nationale de la Recherche sur le SIDA et les hépatites virales
- Fondation pour la Recherche Médicale
- Agence nationale de recherche sur le sida et les hépatites virales
- Fondation Bettencourt Schueller
- Fondation ARC pour la recherche sur le cancer
- Vaincre la Mucoviscidose
- Association Gregory Lemarchal
- Fondation Mérieux
- ECOS-Sud exchange programme (Argentina)
Our team is officially labelled by the Fondation pour la Recherche Médicale (2016-2019 and 2021-2024).
The complete list of our publications is available through Pubmed.
TB vaccine research
Bettencourt, P.J.G., Joosten, S.A., Lindestam Arlehamn, C.S., Behr, M.A., Locht, C., Neyrolles, O. (2021) 100 years of the Bacillus Calmette-Guerin vaccine. Vaccine 39, 7221-7222 (View)
Levillain, F.*, Kim, H.*, Woong Kwon, K., Clark, S., Cia, F., Malaga, W., Lanni, F., Brodin, P., Gicquel, B., Guilhot, C., Bancroft, G.J., Williams, A., Jae Shin, S., Poquet, Y.**, Neyrolles, O.** (2020) Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis. Vaccine 38, 1416-1423 (View)
Voss, G., Casimiro, D., Neyrolles, O., Williams, A., Kaufmann, S.H.E., McShane, H., Hatherill, M., Fletcher, H.A. (2018) Progress and challenges in TB vaccine development. F1000Res 7, 199 (View)
Kaufmann, S.H.E., Dockrell, H.M., Drager, N., Ho, M.M., McShane, H., Neyrolles, O., Ottenhoff, T.H.M., Patel, B., Roordink, D., Spertini, F., Stenger, S., Thole, J., Verreck, F.A.W., Williams, A., Consortium, T. (2017) TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development. Front Immunol 8, 1203 (View)
Scriba, T.J., Kaufmann, S.H., Henri Lambert, P., Sanicas, M., Martin, C., Neyrolles, O. (2016) Vaccination Against Tuberculosis With Whole-Cell Mycobacterial Vaccines. J Infect Dis 214, 659-664 (View)
Immunity to TB, TB/HIV coinfection and other pathogens
Maio, M., Joly, M., Vahlas, Z., Barros, J., Marín Franco, J.L., Genoula, M., Monard, S., Vecchione, M.B., Fuentes, F., Gonzalez Polo, V., Quiroga, M.F., Vermeulen, M., Argüello, R.J., Inwentarz, S., Musella, R., Ciallella, L., González Montaner, P., Palmero, D., Lugo Villarino, G., Sasiain, M.C., Neyrolles O., Verollet, C., Balboa, L. (2023) Elevated glycolytic metabolism of monocytes limits the generation of HIF-1α-driven migratory dendritic cells in tuberculosis. Elife Reviewed preprint (View)
Corral, D., Charton, A., Krauss, M.Z., Blanquart, E., Levillain, F., Lefrancais, E., Sneperger, T., Vahlas, Z., Girard, J.P., Eberl, G., Poquet, Y., Guery, J.C., Arguello, R.J., Belkaid, Y., Mayer-Barber, K.D., Hepworth, M.R., Neyrolles, O.**, Hudrisier, D.** (2022) ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection. Cell Rep 39, 110715 (View)
Bernard-Raichon, L., Colom, A., Monard, S.C., Namouchi, A., Cescato, M., Garnier, H., Leon-Icaza, S.A., Metais, A., Dumas, A., Corral, D., Ghebrendrias, N., Guilloton, P., Verollet, C., Hudrisier, D., Remot, A., Langella, P., Thomas, M., Cougoule, C.**, Neyrolles, O.**, Lugo-Villarino, G**. (2021) A Pulmonary Lactobacillus murinus Strain Induces Th17 and RORgammat(+) Regulatory T Cells and Reduces Lung Inflammation in Tuberculosis. J Immunol 207, 1857-1870 (View)
Marin Franco, J.L., Genoula, M., Corral, D., Duette, G., Ferreyra, M., Maio, M., Dolotowicz, M.B., Aparicio-Trejo, O.E., Patino-Martinez, E., Charton, A., Metais, A., Fuentes, F., Soldan, V., Morana, E.J., Palmero, D., Ostrowski, M., Schierloh, P., Sanchez-Torres, C., Hernandez-Pando, R., Pedraza-Chaverri, J., Rombouts, Y., Hudrisier, D., Layre, E., Verollet, C., Maridonneau-Parini, I., Neyrolles, O., Sasiain, M.D.C., Lugo-Villarino, G., Balboa, L. (2020) Host-Derived Lipids from Tuberculous Pleurisy Impair Macrophage Microbicidal-Associated Metabolic Activity. Cell Rep 33, 108547 (View)
Dupont, M.*, Souriant, S.*, Balboa, L., Vu Manh, T.P., Pingris, K., Rousset, S., Cougoule, C., Rombouts, Y., Poincloux, R., Ben Neji, M., Allers, C., Kaushal, D., Kuroda, M.J., Benet, S., Martinez-Picado, J., Izquierdo-Useros, N., Sasiain, M.D.C., Maridonneau-Parini, I.**, Neyrolles, O.**, Verollet, C.**, Lugo-Villarino, G**. (2020) Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages. Elife 9 (View)
Souriant, S., Balboa, L., Dupont, M., Pingris, K., Kviatcovsky, D., Cougoule, C., Lastrucci, C., Bah, A., Gasser, R., Poincloux, R., Raynaud-Messina, B., Al Saati, T., Inwentarz, S., Poggi, S., Morana, E.J., Gonzalez-Montaner, P., Corti, M., Lagane, B., Vergne, I., Allers, C., Kaushal, D., Kuroda, M.J., Sasiain, M.D.C., Neyrolles, O.**, Maridonneau-Parini, I.**, Lugo-Villarino, G.**, Verollet, C**. (2019) Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages. Cell Rep 26, 3586-3599 e3587 (View) | This article was highlighted in Science
Dumas, A., Corral, D., Colom, A., Levillain, F., Peixoto, A., Hudrisier, D., Poquet, Y., Neyrolles, O. (2018) The Host Microbiota Contributes to Early Protection Against Lung Colonization by Mycobacterium tuberculosis. Front Immunol 9, 2656 (View)
Lugo-Villarino, G., Troegeler, A., Balboa, L., Lastrucci, C., Duval, C., Mercier, I., Benard, A., Capilla, F., Al Saati, T., Poincloux, R., Kondova, I., Verreck, F.A.W., Cougoule, C., Maridonneau-Parini, I., Sasiain, M.D.C., Neyrolles, O. (2018) The C-Type Lectin Receptor DC-SIGN Has an Anti-Inflammatory Role in Human M(IL-4) Macrophages in Response to Mycobacterium tuberculosis. Front Immunol 9, 1123 (View)
Benard, A., Sakwa, I., Schierloh, P., Colom, A., Mercier, I., Tailleux, L., Jouneau, L., Boudinot, P., Al-Saati, T., Lang, R., Rehwinkel, J., Loxton, A.G., Kaufmann, S.H.E., Anton-Leberre, V., O’Garra, A., Sasiain, M.D.C., Gicquel, B., Fillatreau, S.**, Neyrolles, O.**, Hudrisier, D.** (2018) B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis. Am J Respir Crit Care Med 197, 801-813 (View)
Troegeler, A., Mercier, I., Cougoule, C., Pietretti, D., Colom, A., Duval, C., Vu Manh, T.P., Capilla, F., Poincloux, R., Pingris, K., Nigou, J., Rademann, J., Dalod, M., Verreck, F.A., Al Saati, T., Lugo-Villarino, G., Lepenies, B., Hudrisier, D., Neyrolles, O. (2017) C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells. Proc Natl Acad Sci USA 114, E540-E549 (View)
Lastrucci, C., Benard, A., Balboa, L., Pingris, K., Souriant, S., Poincloux, R., Al Saati, T., Rasolofo, V., Gonzalez-Montaner, P., Inwentarz, S., Morana, E.J., Kondova, I., Verreck, F.A., Sasiain Mdel, C., Neyrolles, O.**, Maridonneau-Parini, I.**, Lugo-Villarino, G.**, Cougoule, C.** (2015) Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16(+) monocyte population via the IL-10/STAT3 axis. Cell Res 25, 1333-1351 (View)
Troegeler, A., Lastrucci, C., Duval, C., Tanne, A., Cougoule, C., Maridonneau-Parini, I.**, Neyrolles, O.**, Lugo-Villarino, G.** (2014) An efficient siRNA-mediated gene silencing in primary human monocytes, dendritic cells and macrophages. Immunol Cell Biol 92, 699-708
Lefevre, L.*, Lugo-Villarino, G.*, Meunier, E.*, Valentin, A., Olagnier, D., Authier, H., Duval, C., Dardenne, C., Bernad, J., Lemesre, J.L., Auwerx, J., Neyrolles, O., Pipy, B., Coste, A. (2013) The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum. Immunity 38, 1038-1049 (View)
Tanne, A., Ma, B., Boudou, F., Tailleux, L., Botella, H., Badell, E., Levillain, F., Taylor, M.E., Drickamer, K., Nigou, J., Dobos, K.M., Puzo, G., Vestweber, D., Wild, M.K., Marcinko, M., Sobieszczuk, P., Stewart, L., Lebus, D., Gicquel, B., Neyrolles, O. (2009) A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J Exp Med 206, 2205-2220 (View)
Tailleux, L., Pham-Thi, N., Bergeron-Lafaurie, A., Herrmann, J.L., Charles, P., Schwartz, O., Scheinmann, P., Lagrange, P.H., de Blic, J., Tazi, A., Gicquel, B., Neyrolles, O. (2005) DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosis. PLoS Med 2, e381 (View)
Tailleux, L., Schwartz, O., Herrmann, J.L., Pivert, E., Jackson, M., Amara, A., Legres, L., Dreher, D., Nicod, L.P., Gluckman, J.C., Lagrange, P.H., Gicquel, B., Neyrolles, O. (2003) DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. J Exp Med 197, 121-127 (View)
Maeda, N., Nigou, J., Herrmann, J.L., Jackson, M., Amara, A., Lagrange, P.H., Puzo, G., Gicquel, B., Neyrolles, O. (2003) The cell surface receptor DC-SIGN discriminates between Mycobacterium species through selective recognition of the mannose caps on lipoarabinomannan. J Biol Chem 278, 5513-5516 (View)
Mycobacterial evolution, physiology and virulence
Dupuy, P., Gutierez, C., Neyrolles, O. (2023) Modulation of bacterial membrane proteins activity by clustering into plasma membrane nanodomains. Mol Microbiol (View)
Boudehen, Y.M.*, Faucher, M.*, Marechal, X., Miras, R., Rech, J., Rombouts, Y., Seneque, O., Wallat, M., Demange, P., Bouet, J.Y., Saurel, O., Catty, P., Gutierrez, C., Neyrolles, O. (2022) Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms. Nat Commun 13, 4731 (View)
Freire, D.M.*, Gutierrez, C.*, Garza-Garcia, A., Grabowska, A.D., Sala, A.J., Ariyachaokun, K., Panikova, T., Beckham, K.S.H., Colom, A., Pogenberg, V., Cianci, M., Tuukkanen, A., Boudehen, Y.M., Peixoto, A., Botella, L., Svergun, D.I., Schnappinger, D., Schneider, T.R., Genevaux, P., de Carvalho, L.P.S., Wilmanns, M., Parret, A.H.A.**, Neyrolles, O.** (2019) An NAD(+) Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death. Mol Cell 73, 1282-1291 e1288 (View)
Levillain, F.*, Poquet, Y.*, Mallet, L., Mazeres, S., Marceau, M., Brosch, R., Bange, F.C., Supply, P., Magalon, A., Neyrolles, O. (2017) Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation. PLoS Pathog 13, e1006752 (View)
Neyrolles, O., Wolschendorf, F., Mitra, A., Niederweis, M. (2015) Mycobacteria, metals, and the macrophage. Immunol Rev 264, 249-263 (View)
Gouzy, A., Poquet, Y., Neyrolles, O. (2014) Nitrogen metabolism in Mycobacterium tuberculosis physiology and virulence. Nat Rev Microbiol 12, 729-737
Gouzy, A., Larrouy-Maumus, G., Bottai, D., Levillain, F., Dumas, A., Wallach, J.B., Caire-Brandli, I., de Chastellier, C., Wu, T.D., Poincloux, R., Brosch, R., Guerquin-Kern, J.L., Schnappinger, D., Sorio de Carvalho, L.P., Poquet, Y., Neyrolles, O. (2014) Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection. PLoS Pathog 10, e1003928 (View)
Gouzy, A., Larrouy-Maumus, G., Wu, T.D., Peixoto, A., Levillain, F., Lugo-Villarino, G., Guerquin-Kern, J.L., de Carvalho, L.P., Poquet, Y., Neyrolles, O. (2013) Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate. Nat Chem Biol 9, 674-676 (View)
Botella, H., Stadthagen, G., Lugo-Villarino, G., de Chastellier, C., Neyrolles, O. (2012) Metallobiology of host-pathogen interactions: an intoxicating new insight. Trends Microbiol 20, 106-112
Botella, H., Peyron, P., Levillain, F., Poincloux, R., Poquet, Y., Brandli, I., Wang, C., Tailleux, L., Tilleul, S., Charriere, G.M., Waddell, S.J., Foti, M., Lugo-Villarino, G., Gao, Q., Maridonneau-Parini, I., Butcher, P.D., Castagnoli, P.R., Gicquel, B., de Chastellier, C., Neyrolles, O. (2011) Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages. Cell Host Microbe 10, 248-259 (View)
Brodin, P., Poquet, Y.*, Levillain, F.*, Peguillet, I.*, Larrouy-Maumus, G., Gilleron, M., Ewann, F., Christophe, T., Fenistein, D., Jang, J., Jang, M.S., Park, S.J., Rauzier, J., Carralot, J.P., Shrimpton, R., Genovesio, A., Gonzalo-Asensio, J.A., Puzo, G., Martin, C., Brosch, R., Stewart, G.R., Gicquel, B., Neyrolles, O. (2010) High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling. PLoS Pathog 6, e1001100 (View)
Becq, J., Gutierrez, M.C., Rosas-Magallanes, V., Rauzier, J., Gicquel, B., Neyrolles, O.** Deschavanne, P.** (2007) Contribution of horizontally acquired genomic islands to the evolution of the tubercle bacilli. Mol Biol Evol 24, 1861-1871 (View)
Rosas-Magallanes, V., Deschavanne, P., Quintana-Murci, L., Brosch, R., Gicquel, B., Neyrolles, O. (2006) Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis. Mol Biol Evol 23, 1129-1135 (View)
A nice paper you may want to read…
Neyrolles, O., Hernandez-Pando, R., Pietri-Rouxel, F., Fornes, P., Tailleux, L., Barrios Payan, J.A., Pivert, E., Bordat, Y., Aguilar, D., Prevost, M.C., Petit, C., Gicquel, B. (2006) Is adipose tissue a place for Mycobacterium tuberculosis persistence? PLoS One 1, e43 (View)
We are extremely proud of our former research assistants, PhD students and post-doctoral fellows who are now continuing their career in the best labs, enterprises and institutions in life sciences!
- Tamara Sneperger | Post-doctoral fellow, University of Edinburgh, UK
- Aurélien Boyancé | Project manager, Evotec, Toulouse, France
- Benjamin Raymond | Post-doctoral fellow, University of Newcastle, UK
- Yves-Marie Boudhen | Post-doctoral fellow, IRIM, Montpellier, France
- Alison Charton | Research assistant, Evotec, Toulouse, France
- Dan Corral | Post-doctoral fellow, NIAID, NIH, Bethesda, MD, USA
- Giulia Trimaglio | Post-doctoral fellow, Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Technische Universität Dresden, Germany
- Lucie Bernard-Raichon | Post-doctoral fellow, New York University, NY, USA
- Maeva Dupont | Post-doctoral fellow, University of Oxford, UK
- Alexia Dumas | Post-doctoral fellow, University College Dublin, Ireland – Present: Post-doctoral fellow, IRSD, Toulouse, France
- Karine Pingris | Research engineer, Evotec, Toulouse, France
- André Colom | Research assistant, Evotec, Toulouse, France
- Danilo Pietretti | Project officer, European Commission
- Alan Bénard | Post-doctoral fellow, University Hospital, Erlangen, Germany
- Anthony Troegeler | Research associate, Evotec, Toulouse, France
- Anna Grabowska | Associate professor, Medical University of Warsaw, Warsaw, Poland
- Kanjana Nukdee | Professor, Ubon Ratchathani University, Thailand
- Ingrid Mercier | Business Project Leader, Airbus group, Toulouse, France
- Alexandre Gouzy | Post-doctoral fellow, Weill Cornell Medical College, NY, USA
- Hélène Botella | Post-doctoral fellow, Weill Cornell Medical College, NY, USA – Present: Post-doctoral fellow, Imperial College, London, UK
- Antoine Tanne | Immune Modulatory Drug Development Specialist (I/O – Vaccines), Boston, MA
- Jichan Jang | Professor, Gyeongsang National University, Jinju, South Korea
- Chongzhen Wang | Associate professor, Guilin Medical College, Guilin, China
- Chuan Wang | Lecturer, Fudan University, Shanghai, China