Pain-free electrochemotherapy
Electrochemotherapy is an innovative technique that enhances the effectiveness of certain anticancer treatments through the application of electrical pulses. However, these pulses cause painful muscle contractions, which usually require regional or general anesthesia.
To overcome this limitation and make the treatment more comfortable, a team at IPBS has developed a groundbreaking protocol combining a high-frequency generator with a multipolar electrode. Tested on several cellular models as well as on cats and horses in veterinary clinics, this new approach significantly reduces pain while maintaining treatment efficacy.
Conducted in partnership with Leroy Biotech and veterinarians from Toulouse-based clinics, this study demonstrates that electrochemotherapy can be administered under mild sedation, thereby minimizing anesthesia-related risks and improving patient well-being. These advances pave the way for broader clinical applications of this technique in veterinary oncology and could, in the future, also benefit human medicine.
Reference
“New effective and less painful high frequency electrochemotherapy protocols: from optimization on 3D models to pilot study on veterinary patients”. Alexia de Caro, Jean-Baptiste Leroy, Loïck Royant, David Sayag, Ilaria Marano, Elodie Lallemand, Marion Toussaint, Jelena Kolosnjaj-Tabi, Marie-Pierre Rols and Muriel Golzio. Journal of Controlled Release
Contact Scientist
Muriel Golzio | Muriel.Golzio@ipbs.fr