Here are our main recent publications. The complete list is available on PubMed.

Lagarrigue, F., Tan, B., Du, Q., Fan, Z., Lopez-Ramirez, M.A., Gingras, A.R., Wang, H., Qi, W., Sun, H. (2022) Direct binding of Rap1 to Talin1 and to MRL proteins promotes integrin activation in CD4+ T cells. J Immunol 208, 1378-1388
Lee, H.S.*, Sun, H.*, Lagarrigue, F.*, Kim, S.H.J., Fox, J.W., Sherman, N.E., Gingras, A.R., Ginsberg, M.H. (2022) Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs. J Exp Med 219: e20211637
Sun, H., Lagarrigue, F., Ginsberg, M.H. (2022) The connection between Rap1 and Talin1 in the activation of integrins in blood cells. Front Cell Dev Biol 10 :908622

Lagarrigue, F., Gingras, A.R. (2021) Src-mediated phosphorylation of RIAM promotes integrin activation. Structure 296: 100675
Sun, H., Lagarrigue, F., Wang, H., Fan, Z., Lopez-Ramirez, M.A., Chang, J.T., Ginsberg, M.H. (2021) Distinct integrin activation pathways for effector and regulatory T cell trafficking and function. J Exp Med 218: e20201524

Lagarrigue, F.*, Paul, D.S.*, Gingras, A.R.*, Valadez, A.J., Sun, H., Lin, J., Cuevas, M.N., Ablack, J.N., Lopez-Ramirez, M.A., Bergmeier, W., Ginsberg, M.H. (2020) Talin-1 is the principal platelet Rap1 effector of integrin activation. Blood 136, 1180-1190
Ablack, J.N., Ortiz, J., Bajaj, J., Trinh, K., Lagarrigue, F., Cantor, J.M., Reya, T., Ginsberg, M.H., MARCH proteins mediate responses to antitumor antibodies. J Immunol 205, 2883-2892

Gingras, A.R.*, Lagarrigue, F.*, Cuevas, M.N., Valadez, A.J., Zorovich, M., McLaughlin, W., Lopez-Ramirez, M.A., Seban, N., Ley, K., Kiosses, W.B., Ginsberg M.H. (2019) Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem. J Cell Biol 218, 1799-1809

Lagarrigue, F., Gingras, A.R., Paul, D.S., Valadez, A.R., Cuevas, M.N., Sun, H., Lopez-Ramirez, M.A., Goult, B.T., Shattil, S.J., Bergmeier, W., Ginsberg, M.H. (2018) Rap1 binding to the talin1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. Blood Adv 2, 2358-2368
Sun, H., Lagarrigue, F., Gingras, A.R., Fan, Z., Ley, K., Ginsberg, M.H. (2018) Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development. J Cell Biol 217, 1453-1465

Lagarrigue, F., Gertler, F.B., Ginsberg, M.H., Cantor, J.M. (2017) Cutting Edge: Loss of T cell RIAM precludes conjugate formation with APC and prevents immune-mediated diabetes. J Immunol 198, 3410-3415

Lagarrigue, F., Kim, C., Ginsberg, M.H. (2016) The Rap1-RIAM-talin axis of integrin activation and blood cell function. Blood 128, 479-487

Lagarrigue, F.*, Vikas Anekal, P.*, Lee, H.S., Bachir, A.I., Ablack, J.N., Horwitz, A.F., Ginsberg, M.H. (2015) A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration. Nat Commun 6:8492

Ye, F.*, Lagarrigue, F.*, Ginsberg, M.H. (2014) SnapShot: talin and the modular nature of the integrin adhesome. Cell 156, 1340-1340.e1