Publications

2025

Gorse L, Plessis L, Wearne S, Paradis M, Pinilla M, Chua R, Lim SS, Pelluz E, Toh GA, Mazars R, Bomfim C, Hervé F, Lhaute K, Réveillon D, Suire B, Ravon-Katossky L, Benoist T, Fromont L, Péricat D, Neil Mertens K, Derrien A, Terre-Terrillon A, Chomérat N, Bilien G, Séchet V, Carpentier L, Fall M, Sonko A, Hakim H, Sadio N, Bourdeaux J, Cougoule C, Henras AK, Perez-Oliva AB, Brehmer P, Roca FJ, Zhong FL, Common J, Meunier E*, Hess P.* * shared study lead. Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation. EMBO Mol Med. 2025 Mar;17(3):535-562. doi: 10.1038/s44321-025-00197-4. Epub 2025 Feb 13.

2024

Blot C, Lavernhe M, Lugo-Villarino G, Coulson K, Salon M, Tertrais M, Planès R, Santoni K, Authier H, Jacquemin G, Rahabi M, Parny M, Letron IR, Meunier E*, Lefèvre L*, Coste A*. * shared study lead Leishmania infantum exploits the anti-ferroptosis effects of Nrf2 to escape cell death in macrophages. Cell Rep. 2024 Sep 24;43(9):114720. doi: 10.1016/j.celrep.2024.114720. Epub 2024 Sep 7.

Rozario P, Pinilla M, Gorse L, Vind AC, Robinson KS, Toh GA, Firdaus MJ, Martínez JF, Kerk SK, Lin Z, Chambers JC, Bekker-Jensen S, Meunier E*, Zhong F*. * shared study lead. Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2309579121. doi: 10.1073/pnas.2309579121. Epub 2024 Jan 4.

2023

Pinilla M, Mazars R, Vergé R, Gorse L, Paradis M, Suire B, Santoni K, Robinson KS, Toh GA, Prouvensier L, Leon-Icaza SA, Hessel A, Péricat D, Murris M, Guet-Revillet H, Henras A, Buyck J, Ravet E, Zhong FL, Cougoule C, Planès R, Meunier E. EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption. J Exp Med. 2023 Oct 2;220(10):e20230104. doi: 10.1084/jem.20230104. Epub 2023 Aug 29.

Leon-Icaza SA, Bagayoko S, Vergé R, Iakobachvili N, Ferrand C, Aydogan T, Bernard C, Sanchez Dafun A, Murris-Espin M, Mazières J, Bordignon PJ, Mazères S, Bernes-Lasserre P, Ramé V, Lagarde JM, Marcoux J, Bousquet MP, Chalut C, Guilhot C, Clevers H, Peters PJ, Molle V, Lugo-Villarino G, Cam K, Berry L, Meunier E, Cougoule C. Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids. PLoS Pathog. 2023 Aug 24;19(8):e1011559. doi: 10.1371/journal.ppat.1011559. eCollection 2023 Aug.

2022

Planès R, Pinilla M, Santoni K, Hessel A, Passemar C, Lay K, Paillette P, Valadão AC, Robinson KS, Bastard P, Lam N, Fadrique R, Rossi I, Pericat D, Bagayoko S, Leon-Icaza SA, Rombouts Y, Perouzel E, Tiraby M; COVID Human Genetic Effort; Zhang Q, Cicuta P, Jouanguy E, Neyrolles O, Bryant CE, Floto AR, Goujon C, Lei FZ, Martin-Blondel G, Silva S, Casanova JL, Cougoule C, Reversade B, Marcoux J, Ravet E, Meunier E. Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells. Mol Cell. 2022 Jul 7;82(13):2385-2400.e9. doi: 10.1016/j.molcel.2022.04.033. Epub 2022 May 16.

Iakobachvili N, Leon-Icaza SA, Knoops K, Sachs N, Mazères S, Simeone R, Peixoto A, Bernard C, Murris-Espin M, Mazières J, Cam K, Chalut C, Guilhot C, López-Iglesias C, Ravelli RBG, Neyrolles O, Meunier E, Lugo-Villarino G, Clevers H, Cougoule C*, Peters PJ*. * shared study lead. Mycobacteria-host interactions in human bronchiolar airway organoids. Mol Microbiol. 2022 Mar;117(3):682-692. doi: 10.1111/mmi.14824. Epub 2021 Nov 5.

Santoni K, Pericat D, Gorse L, Buyck J, Pinilla M, Prouvensier L, Bagayoko S, Hessel A, Leon-Icaza SA, Bellard E, Mazères S, Doz-Deblauwe E, Winter N, Paget C, Girard JP, Pham CTN, Cougoule C, Poincloux R, Lamkanfi M, Lefrançais E, Meunier E, Planès R. Caspase-1-driven neutrophil pyroptosis and its role in host susceptibility to Pseudomonas aeruginosa. PLOS Pathog 2022 Jul 18;18(7):e1010305. doi: 10.1371/journal.ppat.1010305

Planès R, Pinilla M, Santoni K, Hessel A, Passemar C, Lay K, Paillette P, Valadão AC, Robinson KS, Bastard P, Lam N, Fadrique R, Rossi I, Pericat D, Bagayoko S, Leon-Icaza SA, Rombouts Y, Perouzel E, Tiraby M; COVID Human Genetic Effort; Zhang Q, Cicuta P, Jouanguy E, Neyrolles O, Bryant CE, Floto AR, Goujon C, Lei FZ, Martin-Blondel G, Silva S, Casanova JL, Cougoule C, Reversade B, Marcoux J, Ravet E, Meunier E. Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells. Mol Cell 2022 Jul 7;82(13):2385-2400.e9. doi: 10.1016/j.molcel.2022.04.03

2021

Bagayoko S, Leon-Icaza SA, Pinilla M, Hessel A, Santoni K, Péricat D, Bordignon PJ, Moreau F, Eren E, Boyancé A, Naser E, Lefèvre L, Berrone C, Iakobachvili N, Metais A, Rombouts Y, Lugo-Villarino G, Coste A, Attrée I, Frank DW, Clevers H, Peters PJ, Cougoule C, Planès R, Meunier E. Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology. PLOS Pathog 2021 Sep 13;17(9):e1009927. doi: 10.1371/journal.ppat.1009927

2020

Eren E, Planès R, Bagayoko S, Bordignon PJ, Chaoui K, Hessel A, Santoni K, Pinilla M, Lagrange B, Burlet-Schiltz O, Howard JC, Henry T, Yamamoto M, Meunier E.Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response. EMBO Rep 2020 Nov 5;21(11):e50829. doi: 10.15252/embr.202050829

2018

Santos JC, Dick MS, Lagrange B, Degrandi D, Pfeffer K, Yamamoto M, Meunier E, Pelczar P, Henry T, Broz P. LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation. EMBO J 2018 Mar 15;37(6):e98089. doi: 10.15252/embj.201798089

2015

Meunier E, Wallet P, Dreier RF, Costanzo S, Anton L, Rühl S, Dussurgey S, Dick MS, Kistner A, Rigard M, Degrandi D, Pfeffer K, Yamamoto M, Henry T, Broz P. Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida. Nat Immunol 2015 May;16(5):476-484. doi: 10.1038/ni.3119