Publications & Patents

The complete list of our publications is available through Pubmed

Lipid presentation to CD1-restricted T cells

Gilleron, M., Lepore, M., Layre, E., Cala-De Paepe, D., Mebarek, N., Shayman, J.A., Canaan, S., Mori, L., Carriere, F., Puzo, G., De Libero, G. (2016) Lysosomal Lipases PLRP2 and LPLA2 Process Mycobacterial Multi-acylated Lipids and Generate T Cell Stimulatory Antigens. Cell Chem Biol 23, 1147-1156 Pubmed

Garcia-Alles, L.F., Collmann, A., Versluis, C., Lindner, B., Guiard, J., Maveyraud, L., Huc, E., Im, J.S., Sansano, S., Brando, T., Julien, S., Prandi, J., Gilleron, M., Porcelli, S.A., de la Salle, H., Heck, A.J., Mori, L., Puzo, G., Mourey, L., De Libero, G. (2011) Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids. Proc Natl Acad Sci USA 108, 17755-17760 Pubmed

Guiard, J., Collmann, A., Gilleron, M., Mori, L., De Libero, G., Prandi, J., Puzo, G. (2008) Synthesis of diacylated trehalose sulfates: candidates for a tuberculosis vaccine. Angew Chem Int Ed Engl 47, 9734-9738 Pubmed

De la Salle, H., Mariotti, S., Angenieux, C., Gilleron, M., Garcia-Alles, L.F., Malm, D., Berg, T., Paoletti, S., Maitre, B., Mourey, L., Salamero, J., Cazenave, J.P., Hanau, D., Mori, L., Puzo, G., De Libero, G. (2005) Assistance of microbial glycolipid antigen processing by CD1e. Science 310, 1321-1324 Pubmed

Gilleron, M., Stenger, S., Mazorra, Z., Wittke, F., Mariotti, S., Bohmer, G., Prandi, J., Mori, L., Puzo, G., De Libero, G. (2004) Diacylated sulfoglycolipids are novel mycobacterial antigens stimulating CD1-restricted T cells during infection with Mycobacterium tuberculosisJ Exp Med 199, 649-659 Pubmed

Modulation of innate immune response by mycobacteria

Mosquera-Restrepo, S.F., Zuberogoitia, S., Gouxette, L., Layre, E., Gilleron, M., Stella, A., Rengel, D., Burlet-Schiltz, O., Caro, A.C., Garcia, L.F., Segura, C., Pelaez Jaramillo, C.A., Rojas, M., Nigou, J. (2022) A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection. Nat Commun 13, 7751 Pubmed

Bah, A., Sanicas, M., Nigou, J., Guilhot, C., Astarie-Dequeker, C., Vergne, I. (2020) The Lipid Virulence Factors of Mycobacterium tuberculosis Exert Multilayered Control over Autophagy-Related Pathways in Infected Human Macrophages. Cells 9, 666 Pubmed

Blanc, L., Gilleron, M., Prandi, J., Song, O.R., Jang, M.S., Gicquel, B., Drocourt, D., Neyrolles, O., Brodin, P., Tiraby, G., Vercellone, A., Nigou, J. (2017) Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids. Proc Natl Acad Sci USA 114, 11205-11210 Pubmed

Decout A., Silva-Gomes S., Drocourt D., Barbe S., André I., Cueto F.J., Lioux T., Sancho D., Pérouzel E., Vercellone A., Prandi J., Gilleron M., Tiraby G. & Nigou J. (2017) Rational design of adjuvants targeting the C-type lectin Mincle. Proc Natl Acad Sci USA 114:2675-2680 Pubmed

Blattes, E., Vercellone, A., Eutamene, H., Turrin, C.O., Theodorou, V., Majoral, J.P., Caminade, A.M., Prandi, J., Nigou, J., Puzo, G. (2013) Mannodendrimers prevent acute lung inflammation by inhibiting neutrophil recruitment. Proc Natl Acad Sci USA 110, 8795-8800 Pubme

Liu, C.F., Tonini, L., Malaga, W., Beau, M., Stella, A., Bouyssie, D., Jackson, M.C., Nigou, J., Puzo, G., Guilhot, C., Burlet-Schiltz, O., Riviere, M. (2013) Bacterial protein-O-mannosylating enzyme is crucial for virulence of Mycobacterium tuberculosisProc Natl Acad Sci USA 110, 6560-6565 Pubmed

Biosynthesis and structural analysis of lipids and glycoconjugates

Tonini, L., Sadet, B., Stella, A., Bouyssie, D., Nigou, J., Burlet-Schiltz, O., Riviere, M. (2020) Potential Plasticity of the Mannoprotein Repertoire Associated to Mycobacterium tuberculosis Virulence Unveiled by Mass Spectrometry-Based Glycoproteomics. Molecules 25, 2348 Pubmed

Vetizou, M., Pitt, J.M., Daillere, R., Lepage, P., Waldschmitt, N., Flament, C., Rusakiewicz, S., Routy, B., Roberti, M.P., Duong, C.P., Poirier-Colame, V., Roux, A., Becharef, S., Formenti, S., Golden, E., Cording, S., Eberl, G., Schlitzer, A., Ginhoux, F., Mani, S., Yamazaki, T., Jacquelot, N., Enot, D.P., Berard, M., Nigou, J., Opolon, P., Eggermont, A., Woerther, P.L., Chachaty, E., Chaput, N., Robert, C., Mateus, C., Kroemer, G., Raoult, D., Boneca, I.G., Carbonnel, F., Chamaillard, M., Zitvogel, L. (2015) Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 350, 1079-1084 Pubmed

Larrouy-Maumus, G., Skovierova, H., Dhouib, R., Angala, S.K., Zuberogoitia, S., Pham, H., Villela, A.D., Mikusova, K., Noguera, A., Gilleron, M., Valentinova, L., Kordulakova, J., Brennan, P.J., Puzo, G., Nigou, J., Jackson, M. (2012) A small multidrug resistance-like transporter involved in the arabinosylation of arabinogalactan and lipoarabinomannan in mycobacteria. J Biol Chem 287, 39933-39941 Pubmed


Klionsky, D., …, Vergne, I., et al. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17:1-382

Layre, E. (2020) Trafficking of Mycobacterium tuberculosis Envelope Components and Release Within Extracellular Vesicles: Host-Pathogen Interactions Beyond the Wall. Front Immunol 11, 1230

Galais, M., Pradel, B., Vergne, I., Robert-Hebmann, V., Espert, L., Biard-Piechaczyk, M. (2019) [LAP (LC3-associated phagocytosis): phagocytosis or autophagy?]. Med Sci (Paris) 35, 635-642

Bah, A., Vergne, I. (2017) Macrophage Autophagy and Bacterial Infections. Front Immunol 8, 1483 Pubmed

Vergne, I., Lafont, F., Espert, L., Esclatine, A., Biard-Piechaczyk, M. (2017) [Autophagy, ATG proteins and infectious diseases]. Med Sci (Paris) 33, 312-318 Special Issue on “Autophagie”, editorial: Patrice Codogno et Guido Kroemer. Pubmed

Vergne, I., Gilleron, M., Nigou, J. (2014) Manipulation of the endocytic pathway and phagocyte functions by Mycobacterium tuberculosis lipoarabinomannan. Front Cell Infect Microbiol 4, 187 Pubmed

Layre, E., Mazurek, J., Gilleron, M. (2015) Glycolipid Presentation by CD1. In: eLS. John Wiley & Sons, Ltd: Chichester. DOI:10.1002/9780470015902.a0020182.pub2

Ray, A., Cot, M., Puzo, G., Gilleron, M., Nigou, J. (2013) Bacterial cell wall macroamphiphiles: pathogen-/microbe-associated molecular patterns detected by mammalian innate immune system. Biochimie 95, 33-42 Pubmed


Dendrimères à terminaison saccharide à visée anti-inflammatoire. Blattes, E., Puzo, G., Prandi, J., Nigou, J., Vercellone, A., Majoral, J.P., Turrin, C.O., Caminade A.M. Patent n° 10 56902 (FR, 31/08/2010), 11764827.9 (EU, 31/08/2011), 13/819872 (USA, 31/08/2011).

Pharmaceutical compositions comprising actinomycete glycerol acyl derivatives antigens, their process of extraction, and their use against tuberculosis. Puzo, G., Layre, E., Gilleron, M., Prandi, J., Stenger, S., De Libero, G. EP20070291249, deposited 12/10/2007, extended 13/10/2008.

Composition pour la prévention et/ou le traitement des maladies associées à la surexpression du TNF et/ou de l’IL12. Quesniaux, V., Gilleron, M., Puzo, G., Nigou, J. FR20060010136, deposited 20/11/2006, extended 20/11/2007.

Sulfoglycolipid antigens, their process of preparation, and their use against tuberculosis. Puzo, G., Prandi, J., Gilleron, M., De Libero, G., Guiard, J., Mori, L., Paoletti, S. EP20070290097, deposited 24/01/2007, extended 13/10/2008.

Sulfoglycolipid antigens, their extraction from Mycobacterium tuberculosis, and their use against tuberculosis. Puzo, G., Gilleron, M., Stenger, S., De Libero, G. EP20030290965, deposited 18/04/2003.