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Structural Biophysics

Lionel Mourey

Group Leader

The activity of our group goes from fundamental to applied research in the fields of structural biology, biophysics and screening. Our expertise covers all the steps from engineering to biochemical, biophysical and structural characterization of challenging macromolecular assemblies and macromolecule-ligand complexes with great interest in pharmaceutical and biotechnological research.


An important objective of our team is to be a major player in the development of molecular biophysics, integrative structural biology, and ligand screening and design.

Our group develops four research topics (described below). Our research benefits from strong collaborations with laboratories in the Toulouse area, including teams at IPBS, as well as national and international networking. This reflects our commitment to providing the scientific and medical communities with tools that we believe play a major role in answering relevant biological questions, helping to combat diseases and furnishing bio-based tools to tackle technological challenges. In line with this, our biophysical and crystallographic equipment is part of the Integrated Screening Platform of Toulouse (PICT), a national IBiSA platform run under the quality management system standards ISO 9001-2015 and NF X50-900. With two Professors and four Associate-Professors, our group is also strongly involved in teaching and training through research.


Main Publications

Grabowska, A.D., Brison, Y., Maveyraud, L., Gavalda, S., Faille, A., Nahoum, V., Bon, C., Guilhot, C., Pedelacq, J.D.*, Chalut, C.*, and Mourey, L.* (2020). Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases. ACS Chem Biol 15:3206-16.


Serres, S., Tardin, C., and Salome, L.* (2020). Single-Molecule Sensing of DNA Intercalating Drugs in Water. Anal Chem 92:8151-8.


Bery, N., Keller, L., Soulie, M., Gence, R., Iscache, A.L., Cherier, J., Cabantous, S., Sordet, O., Lajoie-Mazenc, I., Pedelacq, J.D.*, Favre, G.*, and Olichon, A.* (2019). A Targeted Protein Degradation Cell-Based Screening for Nanobodies Selective toward the Cellular RHOB GTP-Bound Conformation. Cell Chem Biol 26:1544-58 e6.


Guilbaud, S., Salome, L., Destainville, N., Manghi, M., and Tardin, C.* (2019). Dependence of DNA Persistence Length on Ionic Strength and Ion Type. Phys Rev Lett 122:028102.


Guillet, V., Bordes, P., Bon, C., Marcoux, J., Gervais, V., Sala, A.J., Dos Reis, S., Slama, N., Mares-Mejía, I., Cirinesi, A.-M., Maveyraud, L., Genevaux, P.*, and Mourey, L.* (2019). Structural insights into chaperone addiction of toxin-antitoxin systems. Nat Commun 10:782.


Siguier, B., Haon, M., Nahoum, V., Marcellin, M., Burlet-Schiltz, O., Coutinho, P.M., Henrissat, B., Mourey, L., O’Donohue, M.J., Berrin, J.G., Tranier, S.* and Dumon, C. (2014). First structural insights into alpha-Larabinofuranosidases from the two GH62 glycoside hydrolase subfamilies. J Biol Chem 289:5261-73.


Guillet, V., Knibiehler, M., Gregory-Pauron, L., Remy, M.-H., Chemin, C., Raynaud-Messina, B., Bon, C., Kollman, J.M., Agard, D.A., Merdes, A.* and Mourey, L.* (2011). The crystal structure of gamma-tubulin complex protein GCP4 provides insight into microtubule nucleation. Nat Struct Mol Biol 18:915-19.


Pedelacq, J.D.*, Nguyen, H., Cabantous, S., Mark, B.L., Listwan, P., Bell, C., Friedland, N., Lockard, M., Faille, A., Mourey, L., Terwilliger, T.C. and Waldo, G.S.* (2011). Experimental mapping of soluble protein domains using a hierarchical approach. Nucleic Acids Res 39:e125.






Lionel Mourey

CNRS Research director

Eric Clottes

Professor - University of Toulouse

Laurent Maveyraud

Professor - University of Toulouse

Jean-Denis Pedelacq

CNRS Research associate

Laurence Salomé

CNRS Research director

Cécile Bon

Associate Professor - University of Toulouse

Suzana Dos Reis

Associate Professor - University of Toulouse

Catherine Tardin

Associate Professor - University of Toulouse

Samuel Tranier

Associate Professor - University of Toulouse

Research Assistants

Valérie Guillet

CNRS Engineer

Serge Mazères

CNRS Engineer in Microscopy and Spectroscopy

Virginie Nahoum

CNRS Engineer

Julie Rima

University of Toulouse Technician

Lucas Krawczyk

Georges Ndikoum-Matip

PhD Students

Sébastian Castillo







Lab members, †Co-first authors, *Corresponding authors


  • Martins, C.S., Taveneau, C., Castro-Linares, G., Baibakov, M., Buzhinsky, N., Eroles, M., Milanovic, V., Omi, S., Pedelacq, J.D., Iv, F., Bouillard, L., Llewellyn, A., Gomes, M., Belhabib, M., Kuzmic, M., Verdier-Pinard, P., Lee, S., Badache, A., Kumar, S., Chandre, C., Brasselet, S., Rico, F., Rossier, O., Koenderink, G.H., Wenger, J., Cabantous, S.*, and Mavrakis, M.* (2023). Human septins organize as octamer-based filaments and mediate actin-membrane anchoring in cells. J Cell Biol 222


  • Bon, C.*, Cabantous, S., Julien, S., Guillet, V., Chalut, C., Brison, Y., Malaga, W., Rima, J., Sanchez-Dafun, A., Marcoux, J., Gavalda, S., Quémard, A., Waldo, G.S., Guilhot, C., and Mourey, L.* (2022). Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis. BMC Biol 20:147
  • Cornet, J., Preira, P., Salomé, L., Daumas, F., Lagane, B., Destainville, N., Manghi, M., and Dumas, F.* (2022). Protein overexpression can induce the elongation of cell membrane nanodomains. Biophys J
  • Foulquier C., Rivière A., Heulot M., Dos Reis S., Perdu C., Girbal., Pinault M., Dusséaux S.,Yoo M., Soucaille P.*, and Meynial-Salles I. (2022). Molecular characterisation of the missing electron pathways for butanol synthesis in Clostridium acetobutylicum. Nat Commun 0.1038/s41467-022-32269-1
  • Iakobachvili, N., Leon-Icaza, S.A., Knoops, K., Sachs, N., Mazères, S., Simeone, R., Peixoto, A., Bernard, C., Murris-Espin, M., Mazieres, J., Cam, K., Chalut, C., Guilhot, C., Lopez-Iglesias, C., Ravelli, R.B.G., Neyrolles, O., Meunier, E., Lugo-Villarino, G., Clevers, H., Cougoule, C.*, and Peters, P.J.* (2022). Mycobacteria-host interactions in human bronchiolar airway organoids. Mol Microbiol 117:682-92
  • Keleş Atıcı, R., Doğan, S.*, Gündüz, M., Vagolu, S.K., Chebaiki, M., Homberset, H., Lherbet, C., Mourey, L., and Tønjum, T. (2022). Urea derivatives carrying a thiophenylthiazole moiety: design, synthesis and evaluation of antitubercular and InhA inhibitory activities. Drug Dev Res 1-13.
  • Koçak Aslan, E., Han, M.İ., Krishna, V.S., Tamhaev, R., Dengiz, C., Doğan, Ş.D., Lherbet, C., Mourey, L., Tønjum, T., Gündüz, M.G.* (2022). Isoniazid linked to sulfonate esters via hydrazone functionality: design, synthesis, and evaluation of antitubercular activity. Pharmaceuticals 15:1301
  • Le, N.H., Constant, P., Tranier, S., Nahoum, V., Guillet, V., Maveyraud, L., Daffé, M., Mourey, L.*, Verhaeghe, P.*, and Marrakchi, H.* (2022). Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis. Bioorg Med Chem 71:116938
  • Mansour, M., Giudice, E., Xu, X., Akarsu, H., Bordes, P., Guillet, V., Bigot, D.J., Slama, N., D’Urso, G., Chat, S., Redder, P., Flaquet, L., Mourey, L., Gillet, R., and Genevaux, P. (2022). Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis. Nat Commun 13:2641
  • Santoni, K., Pericat, D., Gorse, L., Buyck, J., Pinilla, M., Prouvensier, L., Bagayoko, S., Hessel, A., Leon-Icaza, S.A., Bellard, E., Mazères, S., Doz-Deblauwe, E., Winter, N., Paget, C., Girard, J.P., Pham, C.T.N., Cougoule, C., Poincloux, R., Lamkanfi, M., Lefrancais, E., Meunier, E.*, and Planes, R.* (2022). Caspase-1-driven neutrophil pyroptosis and its role in host susceptibility to Pseudomonas aeruginosa. PLoS Pathog 18:e1010305
  • Shrivastava, S., Sarkar, P., Preira, P., Salomé, L., and Chattopadhyay, A.* (2022). Cholesterol-Dependent Dynamics of the Serotonin(1A) Receptor Utilizing Single Particle Tracking: Analysis of Diffusion Modes. J Phys Chem B 126:6682-90
  • Silva Martins, C., Taveneau, C., Castro-Linares, G., Baibakov, M., Buzhinsky, N., Eroles, M., Milanović, V., Omi, S., Pedelacq, J.D., Francois Iv, Bouillard, L., Llewellyn, A., Gomes, M., Belhabib, M., Kuzmić, M., Verdier-Pinard, P., Lee, S., Badache, A., Kumar, S., Chandre, C., Brasselet, S., Rico, F., Rossier, O., Koenderink, G., Wenger, J., Cabantous, S. *, and Mavrakis M.* (2022). Human septins in cells organize as octamer-based filaments mediating actin-membrane anchoring. J Cell Biol Accepted
  • Soukarié, D., Rousseau, P., Salhi, M., de Caro, A., Escudier, J.M., Tardin, C., Ecochard, V., and Salomé, L.* (2022). Single-Molecule Sandwich Aptasensing on Nanoarrays by Tethered Particle Motion Analysis. Anal Chem 94:4319-27
  • Tapera, M., Kekeçmuhammed, H., Sahin, K. Vagolu, S.K., Lherbet, C., Homberset, H., Chebaiki, M., Tønjum, T., Mourey, L., Zorlu, Y., Durdagi, S, and Sarıpınar, E.* (2022). Synthesis, characterization, anti-tuberculosis activity and molecular modeling studies of thiourea derivatives bearing aminoguanidine moiety. J Mol Struct 1270:133899
  • Tomas, N., Leonelli, D., Campoy, M., Marthey, S., Le, N.H., Rengel, D., Pál, A., Korduláková, J., Martin, V., Eynard, N., Guillet, V., Mourey, L., Daffé, M., Lemassu, A., André-Leroux, G., and Marrakchi, H. (2022). Bioinformatic Mining and Structure-Activity Profiling of Baeyer-Villiger Monooxygenases from Mycobacterium tuberculosis. mSphere 7(2): e00482-21


  • Carivenc, C., Maveyraud, L., Blanger, C., Ballereau, S., Roy-Camille, C., Nguyen, M.C., Génisson, Y., Guilhot, C., Chalut, C.*, Pedelacq, J.-D.*, and Mourey, L.* (2021). Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds. Sci Rep 11:18042.
  • Galy, R., Ballereau, S., Génisson, Y., Mourey, L., Plaquevent, J.-C., and Maveyraud, L.* (2021). Fragment-based ligand discovery applied to the mycolic acid methyltransferase Hma (MmaA4) from Mycobacterium tuberculosis: a crystallographic and molecular modelling study. Pharmaceuticals 14:10.3390/ph14121282
  • Mansat, M., Picot, M., Chicanne, G., Nahoum, V., Gaits-Iacovoni, F., Payrastre, B., Hnia, K., and Viaud, J.* (2021). Liposome-based methods to study protein–phosphoinositide interaction. Botelho, R.J. (eds) Phosphoinositides. Methods Mol Biol 2251:177
  • Payros, D., Alonso, H., Malaga, W., Volle, A., Mazères, S., Dejean, S., Valiere, S., Moreau, F., Balor, S., Stella, A., Combes-Soia, L., Burlet-Schiltz, O., Bouchez, O., Nigou, J., Astarie-Dequeker, C.*, and Guilhot, C.* (2021). Rv0180c contributes to Mycobacterium tuberculosis cell shape and to infectivity in mice and macrophages. PLoS Pathog 17:e1010020


  • Augenstreich, J., Haanappel, E., Sayes, F., Simeone, R., Guillet, V., Mazeres, S., Chalut, C., Mourey, L., Brosch, R., Guilhot, C., and Astarie-Dequeker, C. (2020). Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors. Front Cell Infect Microbiol 10.
  • Barutaut, M., Fournier, P., Peacock, W.F., Evaristi, M.F., Caubere, C., Turkieh, A., Desmoulin, F., Eurlings, L.W.M., van Wijk, S., Rocca, H.B., Butler, J., Koukoui, F., Dambrin, C., Mazères, S., Le Page, S., Delmas, C., Galinier, M., Jung, C., Smih, F., and Rouet, P.* (2020). Insulin-like Growth Factor Binding Protein 2 predicts mortality risk in heart failure. Int J Cardiol 300:245-51
  • Crozat, E.*, Tardin, C., Salhi, M., Rousseau, P., Lablaine, A., Bertoni, T., Holcman, D., Sclavi, B., Cicuta, P., and Cornet, F. (2020). Post-replicative pairing of sister ter regions in Escherichia coli involves multiple activities of MatP. Nat Commun 11:3796
  • Grabowska, A.D., Brison, Y., Maveyraud, L., Gavalda, S., Faille, A., Nahoum, V., Bon, C., Guilhot, C., Pedelacq, J.D.*, Chalut, C.*, and Mourey, L.* (2020). Molecular basis for extender unit specificity of mycobacterial polyketide synthases. ACS Chem Biol 15:3206-3216
  • Maveyraud, L.*, and Mourey, L.* (2020). Protein X-ray Crystallography and Drug Discovery. Molecules 25:1030.​​​​​​​
  • Mizuno, D., Tardin, C., and Schmidt, C.F. (2020). Rapid local compression in active gels is caused by nonlinear network response. Soft Matter 16:9369-82
  • Nguyen, M.C., Saurel, O., Carivenc, C., Gavalda, S., Saitta, S., Tran, M.P., Milon, A., Chalut, C., Guilhot, C., Mourey, L., and Pedelacq, J.-D.* (2020). Conformational flexibility of coenzyme A and its impact on the post-translational modification of acyl carrier proteins by 4’-phosphopantetheinyl transferases. FEBS J.
  • Pedelacq, J.D., Nguyen, M.C., Terwilliger, T.C. & Mourey, L. (2020). A comprehensive review on Mycobacterium tuberculosis targets and drug development from a structural perspective. In Structural Biology in Drug Discovery: Methods, Techniques, and Practices (Renaud, J.P., Ed), Wiley. pp. 545-66.
  • Serres, S., Tardin, C., and Salomé, L.* (2020). Single-Molecule Sensing of DNA Intercalating Drugs in Water. Anal Chem 92:8151-8
  • Shrivastava, S., Sarkar, P., Preira, P., Salomé, L.*, and Chattopadhyay, A.* (2020). Role of Actin Cytoskeleton in Dynamics and Function of the Serotonin(1A) Receptor. Biophys J 118:944-56
  • Sicard, F., Destainville, N., Rousseau, P., Tardin, C., and Manghi, M.* (2020). Dynamical control of denaturation bubble nucleation in supercoiled DNA minicircles. Phys Rev E 101:012403
  • Soukarié, D., Ecochard, V., and Salomé, L.* (2020). DNA-based nanobiosensors for monitoring of water quality. Int J Hyg Environ Health 226:113485.


  • Allemand, J.F., Tardin, C., and Salomé, L.* (2019). Parallelized DNA tethered bead measurements to scrutinize DNA mechanical structure. Methods 169:46-56.
  • Bery, N., Keller, L., Soulie, M., Gence, R., Iscache, A.L., Cherier, J., Cabantous, S., Sordet, O., Lajoie-Mazenc, I., Pedelacq, J.D.*, Favre, G.*, and Olichon, A.* (2019). A Targeted Protein Degradation Cell-Based Screening for Nanobodies Selective toward the Cellular RHOB GTP-Bound Conformation. Cell chemical biology 26:1544-1558.
  • Daudé, D., Vergès, A., Cambon, E., Emond, S., Tranier, S., André, I., and Remaud-Siméon, M. (2019). Neutral Genetic Drift-Based Engineering of a Sucrose-Utilizing Enzyme toward Glycodiversification. ACS Catalysis:1241-52.
  • Garcia-Alles, L.F., Root, K., Maveyraud, L., Aubry, N., Lesniewska, E., Mourey, L., Zenobi, R., and Truan, G. (2019). Occurrence and stability of hetero-hexamer associations formed by beta-carboxysome CcmK shell components. PLoS One 14:e0223877.
  • Guilbaud, S., Salomé, L., Destainville, N., Manghi, M.*, and Tardin, C.* (2019). Dependence of DNA Persistence Length on Ionic Strength and Ion Type. Phys Rev Lett 122:028102
  • Guillet, V., Bordes, P., Bon, C., Marcoux, J., Gervais, V., Sala, A.J., Dos Reis, S., Slama, N., Cirinesi, A.M., Maveyraud, L., Genevaux, P.*, and Mourey, L.* (2019). Structural insights into chaperone addiction of toxin-antitoxin systems. Nat Commun 10:782
  • Ladurantie, C., Coustets, M., Czaplicki, G., Demange, P., Mazères, S., Dauvillier, S., Teissie, J., Rols, M.P., Milon, A., Ecochard, V., Gross, G., and Paquereau, L.* (2019). A protein nanocontainer targeting epithelial cancers: rational engineering, biochemical characterization, drug loading and cell delivery. Nanoscale 11:3248-60.
  • Lavelle, C.*, and Tardin, C.* (2019). Single molecule approaches of nucleic acids conformational changes. Methods 169:1-2
  • Massemin, A., Cabantous, S., Waldo, G.S., and Pedelacq, J.D.* (2019). High-Throughput Isolation of Soluble Protein Domains Using a Bipartite Split-GFP Complementation System. Methods Mol Biol 2025:321-33.
  • Pedelacq, J.D. and Cabantous, S. (2019). Development and Applications of Superfolder and Split Fluorescent Protein Detection Systems in Biology. Int J Mol Sci 20(14), 3479.
  • Pedelacq, J.D., Waldo, G.S., and Cabantous, S. (2019). High-Throughput Protein-Protein Interaction Assays Using Tripartite Split-GFP Complementation. Methods Mol Biol 2025:423-37.
  • Pons, B.J., Bezine, E., Hanique, M., Guillet, V., Mourey, L., Chicher, J., Frisan, T., Vignard, J., and Mirey, G. (2019). Cell transfection of purified cytolethal distending toxin B subunits allows comparing their nuclease activity while plasmid degradation assay does not. PLoS One 14:e0214313.


  • Gervais, V., Muller, I., Mari, P.O., Mourcet, A., Movellan, K.T., Ramos, P., Marcoux, J., Guillet, V., Javaid, S., Burlet-Schiltz, O., Czaplicki, G., Milon, A., and Giglia-Mari, G. (2018). Small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy. J Biol Chem 293:14974-88.
  • Chollet,A., Maveyraud, L. , Lherbet, C., and Bernardes-Génisson, V. (2018). An overview on crystal structures of InhA protein: Apo-form, in complex with its natural ligands and inhibitors. Eur J Med Chem 146:318-343.
  • Menchon, G., Maveyraud, L., and Czaplicki, G. (2018). Molecular Dynamics as a Tool for Virtual Ligand Screening. Methods Mol Biol 1762:145-78.


  • Sala, A.J., Bordes, P., Ayala, S., Slama, N., Tranier, S., Coddeville, M., Cirinesi, A.-M., Castanié-Cornet, M.-P., Mourey, L., and Genevaux, P. (2017). Directed evolution of SecB chaperones toward toxin-antitoxin systems. Proc Natl Acad Sci U S A 114(47):12584-12589.
  • Verges, A., Barbe, S., Cambon, E., Moulis, C., Tranier, S., Remaud-Simeon, M., and Andre, I. (2017) Engineering of anp efficient mutant of Neisseria polysaccharea amylosucrase for the synthesis of controlled size maltooligosaccharides. Carbohydr Polym 173, 403-411.
  • Maveyraud, L. (2017) Strategies for Tackling Drug Resistance in Tuberculosis. in Drug Design: Principles and Applications (Grover, A. ed.), Springer Singapore, Singapore. pp 89-112.
  • Cukier, C. D., Tourdes, A., El-Mazouni, D., Guillet, V., Nomme, J., Mourey, L., Milon, A., Merdes, A., and Gervais, V. (2017) NMR secondary structure and interactions of recombinant human MOZART1 protein, a component of the gamma-tubulin complex. Protein Sci 26:2240-8.
  • Faille, A., Gavalda, S., Slama, N., Lherbet, C., Maveyraud, L., Guillet, V., Laval, F., Quémard, A., Mourey, L.* , Pedelacq, JD.* (2017). Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases. J Mol Biol 429:1554-69.


  • Bordes, P., Sala, A.J., Ayala, S., Texier, P., Slama, N., Cirinesi, A.-M., Guillet, V.Mourey, L., and Genevaux, P. (2016). Chaperone addiction of toxin–antitoxin systems. Nat Commun 7:13339.
  • Brison, Y., Malbert, Y., Czaplicki, G., Mourey, L., Remaud-Simeon, M., and Tranier, S.* (2016). Structural insights into the carbohydrate-binding ability of an alpha-(1—>2) branching sucrase from glycoside-hydrolase family 70. J Biol Chem 291:7527-40.
  • Ceccato, L., Chicanne, G., Nahoum, V., Pons, V., Payrastre, B., Gaits-Iacovoni, F., and Viaud, J. (2016). PLIF: A rapid, accurate method to detect and quantitatively assess protein-lipid interactions. Sci Signal 9:rs2.
  • Cukier, C.D., Maveyraud, L., Saurel, O., Guillet, V., Milon, A., and Gervais, V. (2016). The C-terminal region of the transcriptional regulator THAP11 forms a parallel coiled-coil domain involved in protein dimerization. J Struct Biol 194:337-46.
  • Guillet, V.*, Galandrin, S., Maveyraud, L.Ladevèze, S.Mariaule, V.Bon, C., Eynard, N., Daffé, M., Marrakchi, H., and Mourey, L.* (2016). Insight into structure-function relationships and inhibition of the Fatty Acyl-AMP Ligase (FadD32) orthologs from mycobacteria. J Biol Chem 291:7973-89.
  • Le, N.H., Molle, V., Eynard, N., Miras, M., Stella, A., Bardou, F., Galandrin, S., Guillet, V., Andre-Leroux, G., Bellinzoni, M., Alzari, P., Mourey, L., Burlet-Schiltz, O., Daffe, M., and Marrakchi, H. (2016). Ser/Thr phosphorylation regulates the Fatty Acyl-AMP Ligase activity of FadD32, an essential enzyme in mycolic acid biosynthesis. J Biol Chem 291:22793-805.
  • Martin-Yken, H., Francois, J.M., and Zerbib, D. (2016). Knr4: a disordered hub protein at the heart of fungal cell wall signaling. Cell Microbiol 18:1217-27.
  • Zerbib, D. (2016). Bacterial cell envelopes: composition, architecture, and origin. In Handbook of Electroporation, D. Miklavcic, ed. (Cham: Springer International Publishing), pp. 1-20.


Download the complete list of publications from 2020 to 2002


  • Pr David A. Agard, Department of Biochemistry & Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, USA; structure/function relationships of gamma-tubulin complexes
  • Pr Gennaro De Libero, Department of Immunology, University Hospital, Basel, Switzerland; mycobacterial antigen presentation
  • Pr Albert J. R. Heck, Department of Biomolecular Mass Spectrometry, Utrecht University, Utrecht, the Netherlands;mass spectrometry analysis of CD1 proteins complexes
  • Dr Geoffrey S. Waldo, Bioscience Division, Los Alamos National Laboratory, Los Alamos, USA; domain trapping on polyketide synthases


  • Dr Michel Baltas, LSPCMIB, UMR 5068, Toulouse, France;chemical synthesis and drug design
  • Dr Henri de la Salle, EFS Alsace, U725, Strasbourg, France;crystallographic study of CD1e
  • Dr Pierre Genevaux, LMGM, UMR 5100, Toulouse; Structural studies on toxin-antitoxin-chaperone systems from Mycobacterium tuberculosis
  • Dr Laurent Kremer, DIMNP, UMR 5235, Montpellier; structural studies of enzymes involved in mycolic acid biosynthesis
  • Dr Renaud Lesourne, CPTP, UMR 1043, Toulouse; structural characterization of a new signaling protein family
  • Dr Andreas Merdes, CBD, UMR 5547, Toulouse; structural characterization of GCPs and gamma-tubulin complexes
  • Dr Gilles Prévost, Institut de Bactériologie, EA 3432, Strasbourg, France; bacterial pore-forming toxins
  • Pr Magali Remaud-Siméon, LISBP, UMR 5504, UMR 792, Toulouse, France; structural characterization of enzymes of biotechnological and industrial interest


  • Team Dr M. Daffé; characterization and inhibition of new antituberculous drug targets; deciphering the molecular programming of polyketide synthases from pathogenic mycobacteria
  • Team Dr C. Guilhot; characterization and inhibition of new antituberculous drug targets; deciphering the molecular programming of polyketide synthases from pathogenic mycobacteria
  • Team Pr A. Milon; biophysics, structural biology, structure-based ligand screening
  • Team Dr B. Monsarrat and O. Schiltz; protein characterization by MS
  • Team Dr G. Puzo; mycobacterial antigen presentation

Former group members

  • Thomas ENJALBERT (2021-2022)
  • Laura GUEE (2021)
  • Donna-Joe BIGOT (2020-2021)
  • Coralie CARIVENC (2016-2019)
  • Minh-Chau NGUYEN (2015-2019)
  • Amélie MASSEMIN (2016-2018)
  • Israël MARES-MEJíA (2017-2018)
  • Julian NOMME (2015-2017)
  • Barbara GUYEZ (2013-2016)
  • Audrey TOURDES (2014-2016)
  • Sabine GAVALDA (2012-2015)
  • Cécile CIELAS (2009-2014)
  • Alexandre FAILLE (2009-2013)
  • Romain GALY (2008-2012)
  • Luis Fernando GARCIA-ALLES (2004-2012)
  • Catherine BOTANCH (2012)
  • Karine ROTTIER (2009-2012)
  • Yoann BRISON (2011-2012)
  • Frédéric GUERIN (2008-2012)
  • Béatrice SIGUIER (2010-2011)
  • Fabien BERGERET (2007-2011)
  • Lynn GREGORY-PAURON (2009-2010)
  • Pierre ROBLIN (2004-2007)
  • Fanny BOISSIER (2003-2006)
  • Stéphanie CABANTOUS (2002-2005)



List of former trainees: here