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Isabelle Vergne

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Background and Research activity:

Isabelle Vergne received her PhD in Biophysics in 1998 at Toulouse University (France). She spent several years in the laboratory of Vojo Deretic (USA) as post-doctoral fellow then Research Assistant Professor working on phagosome biology and autophagy in the context of Tuberculosis and HIV. She was recruited as a CNRS researcher in November 2010 and joined the Institute of Pharmacology and Structural Biology to pursue her research on host responses to infections and manipulation by pathogens with a focus on autophagy. She was awarded a Marie Curie career integration grant from European Union in 2011 and received her HDR degree in Cellular Biology from University of Toulouse in 2012.

 

Keywords: Autophagy, Innate Immunity, Lipids

Other main activities in the past ten years:

-Student mentoring, thesis jury member, and teaching at University of New Mexico (USA) and Toulouse

-Editorial board member: Autophagy Journal (Associate Editor), Frontiers in Microbial Immunology (Review Editor), Molecular Innate Immunity  (Review Editor)

-Reviewer for scientifc journals: Nature Microbiology, Autophagy, Journal of Infectious Diseases, Cellular Microbiology, Open Biology, Traffic, Scientific report, Front Cell Infect Microbiol, Methods, Virulence, Pathogens & Disease, Immunology, PLOS ONE.

-Reviewer for funding agencies: Netherlands Organization for Scientific Research, Keck Foundation (USA), European Cooperation in Science and Technology,  Swiss National Science Foundation, Fondation "Vaincre la mucoviscidose", Région Languedoc Roussillon

-Networks:

* CFATG/French Autophagy Network (Scientific Board since 2010, Secretary since 2016, Member)

* European COST Transautophagy (Dissemination Coordinator, Management Committee Substitute and Member)

* European TBVAC2020 (Member)

* International Autophagy Conferences, 2014, Toulouse (Organizer)

* Autophagy Workshop 2015, Les Treilles (Invited speaker)

* Macrophage Club of Toulouse (Member)

-Communication to public:

* French press: Science et Avenir

* French TV: France 5

Publications in the past ten years:

1. Bah A., Vergne I. (2017). Macrophage Autophagy and Bacterial Infections. Front Immunol 8:1483 (Review).

2. Vergne I., Lafont F., Espert L.,Esclatine A., Biard-Piechaczyk M. (2017). Autophagy, ATG proteins and infectious diseases.Médecine/Sciences. 33:312-318. Special Issue on "Autophagie", editorial: Patrice Codogno et Guido Kroemer. (Review in French).

3. Roux AL, Viljoen A, Bah A, Simeone R, Bernut A, Laencina L, Deramaudt T, Rottman M, Gaillard JL, Majlessi L, Brosch R, Girard-Misguich F, Vergne I, de Chastellier C, Kremer L, Herrmann JL. The distinct fate of smooth and rough Mycobacterium abscessus variants inside macrophages. Open Biol. 2016 Nov;6(11). pii: 160185.

4. Bah A, Lacarrière C, Vergne I. Autophagy-Related Proteins Target Ubiquitin-Free Mycobacterial Compartment to Promote Killing in Macrophages. Front Cell Infect Microbiol. 2016 May 11;6:53. doi: 10.3389/fcimb.2016.00053. eCollection 2016 May 11.

5. Espert L, Beaumelle B, Vergne I. Autophagy in Mycobacterium tuberculosis and HIV infections. Front Cell Infect Microbiol. 2015 Jun 2;5:49. doi: 10.3389/fcimb.2015.00049. eCollection 2015 Jun 2. (Review).

6. Vergne I, Gilleron M, Nigou J. Manipulation of the endocytic pathway and phagocyte functions by Mycobacterium tuberculosis lipoarabinomannan. Front Cell Infect Microbiol. 2015 Jan 12;4:187. doi: 10.3389/fcimb.2014.00187. eCollection 2015 Jan 12. (Review).

7. Bah A & Vergne I. Autophagy and Autophagy-Related Proteins in the Immunity against Mycobacterium Tuberculosis. Forum on Immunopathological Diseases and Therapeutics. 6: 217-226. 2015. (Review).

8. Singh SB., Ornatowski W., Vergne I., Naylor J., Delgado M., Roberts E., Ponpuak M., Master S., Pilli M., White E., Komatsu M., Deretic V. Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol. 12:1154-65. 2010. F1000 article factor: 6.

9. Ponpuak M., Davis AS., Roberts EA., Delgado MA., Dinkins C., Zhao Z., Virgin HW. 4th, Kyei GB., Johansen T., Vergne I., Deretic V. Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties. Immunity. 32:329-41. 2010. F1000 article factor: 9. Commented in Immunity: Selective macroautophagy for immunity. Christian Münz 2010 32:329.

10. Vergne I., Deretic V. The role of PI3P phosphatases in the regulation of autophagy. FEBS Lett. 584:1313-8. 2010. (Review). Corresponding author.

11. Deretic V., Delgado M., Vergne I., Master S., De Haro S., Ponpuak M., Singh S. Autophagy in immunity against Mycobacterium tuberculosis: a model system to dissect immunological roles of autophagy. Curr Top Microbiol Immunol. 335:169-88. 2009. (Review).

12. Kyei GB., Dinkins C., Davis AS., Roberts E., Singh SB., Dong C., Wu L., Kominami E., Ueno T., Yamamoto A., Federico M., Panganiban A., Vergne I., Deretic V. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yield in macrophages. J. Cell. Biol. 186:255-68. 2009. Cover art for journal issue. Commented in “In focus article”: HIV uses autophagy for its own means. Nicole LeBrasseur J. Cell Biol. 2009 186: 165.

13. Vergne I., Roberts E., Elmaoued RA., Tosch V., Delgado MA., Proikas-Cezanne T., Laporte J., Deretic V. Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy. Embo J. 28:2244-2258. 2009. Co-Corresponding author.

14. Delgado M., Singh S., De Haro S., Master S., Ponpuak M., Dinkins C., Ornatowski W., Vergne I., Deretic V. Autophagy and pattern recognition receptors in innate immunity. Immunol Rev. 227:189-202. 2009. (Review).

15. Liang C., Lee JS., Inn KS., Gack MU., Li Q., Roberts EA., Vergne I., Deretic V., Feng P., Akazawa C., Jung JU. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat.Cell.Biol. 10:776-87. 2008.  Cited as must read in Faculty 1000.

16. Vergne I., Deretic V. In vitro phagosome-endosome fusion. Methods Mol Biol. 445:301-9. 2008.

17. Schlesinger LS., Azad AK., Torrelles JB., Roberts E., Vergne I., and Deretic V. Determinants of Phagocytosis, Phagosome Biogenesis and Autophagy for Mycobacterium tuberculosis. In Kaufmann, S. H. E. and Britton, W. J., editors. Handbook of Tuberculosis. Immunology and Cell Biology, Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim, Germany. 2008.

18. Davis A.S., I. Vergne, S. Master, G. B. Kyei, J. Chua and V. Deretic. Mechanism of Inducible Nitric Oxide Synthase Exclusion from Mycobacterial Phagosomes. Plos Pathogens. 3:1887-1894. 2007.  Cited as recommended in Faculty 1000.

19. Deretic V., Singh S., Master S., Kyei G., Davis A., Naylor J., de Haro S., Harris J., Delgado M., Roberts E., and I. Vergne. Phosphoinositides in phagolysosome and autophagosome biogenesis. Biochem. Soc. Symp. 74:141-148. 2007. (Review).


Complete list

 

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