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Wendy Le Mouellic

Research project

Deciphering Mycobacterium tuberculosis sulfur metabolism during infection

Mycobacterium tuberculosis, the pathogen responsible for tuberculosis, is an intracellular bacterium that infects mainly macrophages and can persist for a long time in pulmonary lesions called granulomas. To survive and multiply inside macrophages, the bacteria have to acquire nutrients that will fuel their metabolism. While carbon and nitrogen metabolisms of bacterial pathogens have been studied for decades, sulfur metabolism is currently gaining interest. Sulfur is required to synthetize the two sulfur-containing amino acids cysteine and methionine but also to produce mycothiol (the main redox buffer in mycobacteria) and Fe-S clusters of enzymes. Sulfur acquisition is therefore essential for M. tuberculosis survival during infection and pathways of sulfur metabolism could be interesting targets for the development of new antimicrobial strategies. In this context, my PhD project aims at understanding M. tuberculosis sulfur metabolism during infection in vivo.

Curriculum vitae

Education

 

PhD in Microbiology (2020-)

Under the supervision of Drs. Olivier Neyrolles and Yannick Poquet

Funding: Contrat Doctoral Spécifique pour Normalien (ENS Paris-Saclay)

Institute of Pharmacology and Structural Biology (IPBS), Toulouse

 

Diploma of the Ecole Normale Supérieure Paris-Saclay (2016-2020)

Ecole Normale Supérieure Paris-Saclay

 

Master’s degree in fundamental microbiology (2019-2020)

Université de Paris – Institut Pasteur

 

Agrégation Biochimie Génie Biologique (2019)

 

Bachelor’s degree (2016-2017)

Ecole Normale Supérieure Paris-Saclay – Université Paris-Saclay

 

Classe préparatoire BCPST (2014-2016)

Lycée Jean-Baptiste Say, Paris

 

 

Interships

 

2019-2020 (6 months): Understanding the mechanisms involved in the adaptation of Mycobacterium bovis BCG to infection in hypoxic environment

Olivier Neyrolles’ laboratory, under the supervision of Yannick Poquet

Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse - France

 

2018 (2 months): Structure of the bacterial envelope and resistance to osmotic stresses in Escherichia coli

Jean-François Collet’s laboratory, under the supervision of Michael Deghelt

de Duve Institute, Brussels - Belgium

 

2017 (2 months): Implication of the autophagy receptor T6BP in the presentation of MHC Class II-restricted viral antigens   

Arnaud Moris’ laboratory, under the supervision of Clémence Richetta

Centre d’Immunologie et des Maladies Infectieuses (CIMI), Paris - France