Tuberculosis: how the bacterium expels toxic metals to resist the immune system
The tuberculosis bacillus survives inside immune cells by neutralizing toxic metals such as zinc. A[…]
A New Role for IL-33 in Platelet Biology
IPBS is delighted to announce the publication of groundbreaking research led by Dr. Emma Lefrançais[…]
Moesin Protein Controls Bone Remodeling by Regulating Osteoclast Fusion and Function
Researchers at the Institut de Pharmacologie et Biologie Structurale (IPBS) have uncovered a pivotal role[…]
A weak point of the TB bacillus identified
In a study published in PNAS, scientists reveal that the survival of the bacterium responsible[…]
Blood vessels fighting cancer: development of a treatment that enhances the effectiveness of immunotherapy by increasing the entry of ‘killer’ lymphocytes into tumors
Immunotherapy represents a true revolution in cancer treatment. With immunotherapy, some patients with previously incurable[…]
Adjusting for better sealing: the function of DNA polymerases in repairing DNA double-strand breaks
The most serious damage to the DNA molecule is the simultaneous breaking of its two[…]
Pain-free electrochemotherapy
Electrochemotherapy is an innovative technique that enhances the effectiveness of certain anticancer treatments through the[…]
‘The mysterious disease of Senegalese fishermen’: the culprit is a toxic marine microalga
Fishermen returning from fishing, barbed tongue. Saint-Louis / Sénégal – Credits: IRD, Carole Filiu Mouhali[…]
Swarms of magnetic nanorobots to disrupt bacterial biofilms
Infections caused by bacteria organized in biofilms are very difficult to treat. In a study[…]
Keeping Ku in check: The crucial role of DNA-PKcs
Like beads on a necklace, several Ku protein complexes can thread onto DNA from the[…]
The migration of macrophages: a mechanism that deviates from the norm
© Perrine Verdys and Renaud Poincloux In an article published in the EMBO Journal, scientists[…]
PptT in the spotlight: deciphering the mechanism of action of an essential enzyme from Mycobacterium tuberculosis
PptT, a 4′-phosphopantetheinyl transferase from Mycobacterium tuberculosis, is an essential enzyme involved in the synthesis of complex mycobacterial lipids that contribute to the virulence and pathogenicity of the bacillus.
Respiratory allergies: newly discovered molecule plays a major role in triggering inflammation
• Inflammation plays a major role in allergic diseases, affecting at least 17 million people[…]
All addicted to potassium: An immune sensor for potassium deficiency in our cells
In collaboration with the Singapore Technological University, IPBS scientists have shown that our body’s epithelial[…]
IP6: an endogenous small molecule which promotes DNA repair
IP6, inositol hexaphosphate or phytic acid, is a product of cellular metabolism that binds to[…]
Marine sponges inspire a new family of anticancer agents
A new generation of potential anticancer agents has been developed jointly by three labs in[…]
Cystic fibrosis: organoid technology to identify new antimicrobial therapeutic strategies
Cystic fibrosis is the most common rare genetic disease. In these patients, respiratory infections contribute[…]
How PAXX keeps our DNA in check
Monitoring the integrity of DNA is the function of the many repair systems present in[…]
The organisation of carbohydrates on the surface of Mycobacterium tuberculosis facilitates infection
The bacterium Mycobacterium tuberculosis, the agent of human tuberculosis, has developed different strategies to attenuate[…]
Macrophage infection by fusion with HIV-1-infected T lymphocytes: Catch me to fuse
Although antiretroviral therapies are effective in reducing viral load in HIV-1 infected patients, one of[…]
Thomas Gensollen receives a starting grant from the Fondation pour la Recherche Médicale to launch his research project on inflammatory disorders
Inflammatory bowel disease (IBD) and asthma are chronic inflammatory disorders of the gut and airways,[…]
Could a well-known antidepressant prevent severe forms of COVID-19?
In the context of the emergence of new variants of SARS-CoV-2, increasingly resistant to vaccines[…]
Metal efflux platforms in the membrane of bacteria
Scientists have discovered a novel mechanism of resistance to metal intoxication in macrophages involving mobile[…]
Fight against tuberculosis: the structure of an important target unravelled
Despite its importance as a therapeutic target against tuberculosis, the structure of Pks13 (PolyKetide Synthase[…]
Cancer Treatment: Identification of the blood vessels that allow killer lymphocytes to access and destroy tumors
Immunotherapy, a therapeutic strategy aimed at increasing the activity of the immune system in order[…]
BRCA1, a caretaker of centromere integrity
In this study published in the journal “Cell Death and Disease”, IPBS scientists highlight a[…]